Sample size estimation for comparing parameters using dynamic causal modeling.

Brain Connectivity
Nia GouldenShane McKie

Abstract

Functional magnetic resonance imaging (fMRI) has proved to be useful for analyzing the effects of illness and pharmacological agents on brain activation. Many fMRI studies now incorporate effective connectivity analyses on data to assess the networks recruited during task performance. The assessment of the sample size that is necessary for carrying out such calculations would be useful if these techniques are to be confidently applied. Here, we present a method of estimating the sample size that is required for a study to have sufficient power. Our approach uses Bayesian Model Selection to find a best fitting model and then uses a bootstrapping technique to provide an estimate of the parameter variance. As illustrative examples, we apply this technique to two different tasks and show that for our data, ~20 volunteers per group is sufficient. Due to variability between task, volunteers, scanner, and acquisition parameters, this would need to be evaluated on individual datasets. This approach will be a useful guide for Dynamic Causal Modeling studies.

References

Sep 1, 1984·The Journal of Comparative Neurology·M Petrides, D N Pandya
Oct 8, 1993·The Journal of Comparative Neurology·J F Bates, P S Goldman-Rakic
Mar 24, 2000·Cerebral Cortex·C CavadaF Reinoso-Suárez
Sep 3, 2002·Journal of Neuroscience Methods·John E Desmond, Gary H Glover
Oct 23, 2002·ILAR Journal·Ralph B DellRajasekhar Ramakrishnan
Jun 20, 2003·NeuroImage·Barry Horwitz
Sep 2, 2003·NeuroImage·K J FristonW Penny
Apr 28, 2004·NeuroImage·S RobinsonE Moser
Jun 29, 2004·NeuroImage·W D PennyK J Friston
Apr 14, 2005·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Cristina M Del-BenIan M Anderson
Dec 28, 2006·Cerebral Cortex·Scott L Fairhall, Alumit Ishai
Jan 24, 2007·NeuroImage·Bertrand ThirionJean-Baptiste Poline
Feb 9, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Sreepadma P SontyDarren R Gitelman
Apr 12, 2007·Journal of Biosciences·Klaas E StephanKarl J Friston
May 5, 2007·NeuroImage·Marta I GarridoKarl J Friston
Dec 8, 2007·NeuroImage·Alumit Ishai
Mar 25, 2009·NeuroImage·Klaas Enno StephanKarl J Friston
Jun 16, 2009·NeuroImage·Klaas Enno StephanKarl J Friston
Nov 17, 2009·NeuroImage·K E StephanK J Friston
Mar 17, 2010·NeuroImage·Pierre BellecAlan C Evans
Mar 20, 2010·PLoS Computational Biology·Will D PennyAlex P Leff
Jul 6, 2010·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Ian M AndersonRebecca Elliott
Oct 18, 2011·NeuroImage·Gabriele LohmannRobert Turner

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Citations

Jul 16, 2013·NeuroImage·Joshua Kahan, Tom Foltynie
Jul 9, 2016·Cortex; a Journal Devoted to the Study of the Nervous System and Behavior·Holly N PhillipsJames B Rowe
Mar 19, 2020·Brain Connectivity·Pedro Henrique Rodrigues da SilvaRenata Ferranti Leoni
Aug 4, 2021·International Journal of Obesity : Journal of the International Association for the Study of Obesity·Katharina VoigtAntonio Verdejo-Garcia
Oct 5, 2021·Brain Connectivity·Ronald SladkyChristian Windischberger

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Methods Mentioned

BETA
SMA

Software Mentioned

DeclareMathSizes
DCM10
SPM8
DCM
WFU PickAtlas

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