PMID: 7017151Jun 1, 1981Paper

Sampling designs for stereology

Journal of Microscopy
L M Cruz-Orive, Ewald R Weibel

Abstract

The purpose of this paper is to propose the necessary sampling techniques for estimating a global parameter defined in a solid opaque specimen (e.g. the total volume of mitochondria in a given liver, the total capillary surface area in a given lung, etc). The geometry of the specimen often suggests a multi-level or cascade sampling design at different magnifications, whereby the object phase at one level becomes the reference phase in the next level. The final parameter is then estimated as the product of the intermediate ratios with the volume of the specimen, which is estimated independently. Each level can be regarded as an independent sampling design; a given stereological project may be planned in terms of one or more of these designs. Our development is a blend of practical experience and recent theoretical advances on sampling for stereology with well-known sampling techniques previously developed with different purposes in mind.

References

Aug 1, 1978·Journal of Microscopy·W L Nicholson
Jul 1, 1966·The Journal of Cell Biology·E R WeibelW F Scherle
May 1, 1981·Journal of Microscopy·L M Cruz-Orive, A O Myking
Jul 1, 1981·Journal of Microscopy·A E MüllerE R Weibel

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Citations

Feb 1, 1996·The Anatomical Record·S I RuncimanB J Gannon
Dec 24, 1998·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·T KawaguchiK Tanikawa
Jan 1, 1990·Journal of Electron Microscopy Technique·J F Bertram, R P Bolender
Jan 1, 1995·European Journal of Applied Physiology and Occupational Physiology·A J ZamoraJ F Marini
Jan 1, 1987·Journal of Mathematical Biology·T Mattfeldt
Feb 24, 2001·Medical & Biological Engineering & Computing·E RomeroC Veraart
Jul 18, 2008·Annals of Biomedical Engineering·Wayne MitznerJohn Bishai
Mar 1, 1987·Respiration Physiology·T B ZeltnerP H Burri
Jan 1, 1988·Progress in Neurobiology·G Bernroider
Jan 1, 1991·Progress in Neurobiology·J P Royet
Sep 1, 1985·Experimental Eye Research·M D McCartney, D H Dickson
Jan 24, 2002·Journal of Hepatology·Corinne LangLukas Krähenbühl
Jan 28, 2003·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·David N PhamMonica Kraft
Nov 12, 2003·Respiratory Physiology & Neurobiology·P H BurriA N Makanya
May 29, 2000·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·T KawaguchiM Sata
Jun 25, 2004·The New England Journal of Medicine·James C HoggPeter D Paré
Feb 14, 1995·Proceedings of the National Academy of Sciences of the United States of America·G D MassaroD Massaro

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