PMID: 15244848Jul 13, 2004Paper

Sampling tissue volumes using frequency-domain photon migration

Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics
Frédéric BevilacquaV Venugopalan

Abstract

We demonstrate the use of Monte Carlo simulations to generate photon scattering density functions (PSDFs) that represent the tissue volume sampled by steady-state and frequency-domain photon migration. We use these results to illustrate how scaling laws can be developed to determine the mean sampling depth of the multiply scattered photons detected by photon migration methods that remain valid outside the bounds of the standard diffusion approximation, i.e., at small source-detector separations and in media where the optical absorption is significant relative to scattering. Using both the PSDF computation and the newly formulated scaling laws, we focus on a comprehensive description of the effects of source modulation frequency, optical absorption, and source-detector separation on the depth of the sampled tissue volume as well as the sensitivity of frequency-domain photon migration measurements to the presence of a localized absorption heterogeneity.

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Citations

Mar 11, 2006·Journal of Biomedical Optics·Paul SimonsonEnrico Gratton
Feb 1, 2008·IEEE Transactions on Bio-medical Engineering·Sheng-Hao TsengAnthony J Durkin
Sep 16, 2018·Journal of Biomedical Optics·Carole K HayakawaVasan Venugopalan
Jul 1, 2017·Biomedical Optics Express·Tiziano BinzoniFabrizio Martelli
Oct 4, 2005·Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics·J S YouV Venugopalan

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