Abstract
To describe the clinical presentation and unique neurologic manifestations of sandfly viruses (SFVs) in the Jerusalem area. We identified all patients with acute seroconversion to SFV at the Hadassah-Hebrew University Medical Centers during the years 2008-2013 and retrospectively collected and analyzed the clinical and imaging data. Nine patients (ranging from 1.5 to 85 years old) were identified. Presentation included acute neurologic disease, mostly with fever, change in consciousness and behavior, seizures, headache, meningitis, limb paresis, or myelitis. Eight patients had clinical signs of meningitis, meningoencephalitis, or encephalitis alone. Four patients had myelitis. MRI identified pathologic symmetrical changes in the basal ganglia, thalami, and other deep structures in 5 patients, and additional myelitis of the spine was noted on imaging in 3 patients. Seven patients had long-term follow-up: 4 completely recovered and 3 had remaining neurologic sequelae, among them 1 with permanent severe brain damage. Neurologic involvement associated with acute SFV infections is considered to be benign. However, in this series, all 9 patients presented with significant neurologic pathology associated with a unique finding of myeli...Continue Reading
References
Dec 1, 1991·Epidemiology and Infection·R EitremB Niklasson
Sep 25, 1993·Lancet·S Eckford, R Fox
Feb 21, 1998·The Journal of Pediatrics·A BraitoM G Ciufolini
Jul 25, 2000·Emerging Infectious Diseases·A BatiehaP Wijeyaratne
Apr 3, 2001·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·D DionisioC Lupi
Aug 2, 2003·European Journal of Epidemiology·D FrancisciF Baldelli
Sep 23, 2003·Current Opinion in Infectious Diseases·Daniele DionisioMarcello Valassina
Feb 15, 2005·Virology·Maria Grazia CusiClelia Miracco
Oct 18, 2005·Journal of Neurology, Neurosurgery, and Psychiatry·J KuhnM Valassina
Dec 2, 2005·Emerging Infectious Diseases·Rémi N CharrelXavier de Lamballerie
Feb 6, 2009·Emerging Infectious Diseases·Sara Sanbonmatsu-GámezJosé María Navarro-Marí
Jun 3, 2009·Military Medicine·David M Brett-Major, David M Claborn
Jan 22, 2010·The Journal of General Virology·Elyes ZhiouaRemi N Charrel
Jul 24, 2010·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·Bradley S HollidgeSamantha S Soldan
Dec 4, 2010·The International Journal of Neuroscience·Daniele SerataRoberto Tatarelli
Mar 19, 2011·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·A PapaS Bino
Jul 18, 2012·PLoS Neglected Tropical Diseases·Aviad MoncazAlon Warburg
Jul 27, 2012·Transactions of the Royal Society of Tropical Medicine and Hygiene·Kifaya AzmiZiad Abdeen
Aug 8, 2012·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Siraya JaijakulRodrigo Hasbun
Aug 31, 2012·The New England Journal of Medicine·Laura K McMullanStuart T Nichol
Feb 26, 2013·PLoS Neglected Tropical Diseases·Roy FaimanAlon Warburg
May 28, 2013·Vector Borne and Zoonotic Diseases·Christophe N PeyrefitteJérôme Depaquit