Saphenous vein graft protection: effects of c-myc antisense

The Journal of Thoracic and Cardiovascular Surgery
J D MannionA Zalewski

Abstract

Saphenous vein grafting is associated with extensive medial remodeling, characterized by cellular proliferation, loss of smooth muscle cells, and an inflammatory response. In this study, we examined whether unfavorable responses to vein grafting could be modified by the intraoperative application of c-myc antisense oligomers. The intragraft cell proliferation, macrophage infiltration, and medial preservation were examined in a porcine model in the control and antisense-treated groups (n = 36). Saphenous veins showed transmural distribution of oligomers within 30 minutes of the ex vivo incubation. A concentration-dependent inhibition of cell proliferation in the media of saphenous grafts was noted 3 days later (0 to 200 mumol/L, p = 0.005). The growth inhibition was sequence-specific, because control oligomers produced only insignificant effects (20 mumol/L). Vascular effects of c-myc antisense were associated with a significant attenuation of macrophage infiltration in saphenous grafts. A concentration-dependent decrease in tissue edema (p = 0.0005) and the attenuated loss of smooth muscle cells (p = 0.002) were noted in the media of the arterialized venous conduits after c-myc antisense. Direct application of synthetic DNA to ...Continue Reading

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Citations

Sep 25, 1999·Journal of Cellular Physiology·U GalderisiA Giordano
Nov 18, 2000·The Annals of Thoracic Surgery·E RodriguezJ D Mannion
Sep 10, 2003·The Annals of Thoracic Surgery·Enoch F AkowuahChristopher Newman
May 22, 1998·The Annals of Thoracic Surgery·J E O'BrienJ D Mannion
Dec 6, 2001·Journal of Controlled Release : Official Journal of the Controlled Release Society·I FishbeinG Golomb
Apr 16, 2003·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Michael HilkerMichael Buerke
Nov 11, 2009·Cardiovascular Research·José J FusterVicente Andrés
Feb 4, 1999·The Annals of Thoracic Surgery·J D MannionA Zalewski
Jul 2, 2005·Expert Opinion on Emerging Drugs·U GalderisiA Cascino
Aug 31, 2010·Journal of Vascular Surgery·Nicholas D AndersenFrank W LoGerfo
Mar 27, 2012·Current Opinion in Pharmacology·Dominik WiedemannThomas Schachner
Jan 25, 2002·Pathology, Research and Practice·M HilkerU Hake
Mar 29, 2008·Vascular Medicine·Christopher D OwensMichael S Conte
May 31, 2008·Expert Review of Cardiovascular Therapy·Shalini BhardwajSeppo Ylä-Herttuala

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