Saponins: Anti-diabetic principles from medicinal plants - A review

Pathophysiology : the Official Journal of the International Society for Pathophysiology
Olusola Olalekan Elekofehinti

Abstract

Diabetes mellitus (DM) represents a global health problem. It is the most common of the endocrine disorders and is characterized by chronic hyperglycemia due to relative or absolute lack of insulin secretion or insulin actions. According to the World Health Organization projections, the diabetes population is likely to increase to 300 million or more by the year 2025. Current synthetic agents and insulin used effectively for the treatment of diabetes are scarce especially in rural areas, expensive and have prominent adverse effects. Complementary and alternative approaches to diabetes management such as isolation of phytochemicals with anti-hyperglycemic activities from medicinal plants is therefore imperative. Saponins are phytochemical with structural diversity and biological activities. This paper reviews saponins and various plants from which they were isolated as well as properties that make them ideal for antidiabetic remedy.

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Citations

May 3, 2016·Pathophysiology : the Official Journal of the International Society for Pathophysiology·A O IgeP C Onuobia
Jul 5, 2016·Phytochemistry·Jasmeen SidanaOm P Sharma
Oct 25, 2016·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Mariangela MarrelliGiancarlo A Statti
Feb 2, 2017·Pharmaceutical Biology·Marie Carene Nancy Picot, Mohamad Fawzi Mahomoodally
Jan 14, 2017·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Oluwamodupe Cecilia EjelonuIsaac Gbadura Adanlawo
Nov 11, 2017·International Journal of Molecular Sciences·Kumar Ganesan, Baojun Xu
Jul 29, 2017·World Journal of Diabetes·Olusola Olalekan ElekofehintiIsaac Gbadura Adanlawo
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Oct 17, 2018·Journal of Cellular and Molecular Medicine·Jing XuGuangzhong Yang
Apr 21, 2019·Marine Drugs·Sadeer Nabeelah BibiShunmugiah Karutha Pandian
Aug 15, 2020·Natural Product Research·Seham S El-HawaryMona M Okba
Nov 26, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Daria GrzywaczHenryk Myszka
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May 18, 2021·Journal of Pharmaceutical and Biomedical Analysis·Mona A MohammedPiotr Kachlicki
Jul 30, 2020·Current Pharmaceutical Design·Xin WangHelong Quan
Jul 25, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Mayadah Bashir ShehadehAla' Mustafa Abu-Odeh
May 18, 2020·Current Diabetes Reviews·Neeraj ChoudharyAshish Suttee

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