Saponins composition in American ginseng leaf and berry assayed by high-performance liquid chromatography

Journal of Agricultural and Food Chemistry
Chong-Zhi WangChun-Su Yuan

Abstract

The root of American ginseng is a commonly used herbal medicine in the United States. However, the compositions of American ginseng leaves and berries are not clear to date. In this study, we improved a method for the analysis of 12 ginsenosides based on solid phase extraction and high-performance liquid chromatography-ultraviolet. Good resolution was obtained for all tested ginsenosides: Rb1, Rb2, Rb3, Rc, Rd, Re, Rg1, Rg2, 20(R)-Rg2, Rg3, Rh1, and Rh2. Ginsenosides Rh1, Rg2, and 20(R)-Rg2 were easily separated with this column. The modified gradient elution program resulted in satisfactory linearity and precision. Solid phase extraction made the analysis accurate and efficient. Other investigators recently observed that ginsenoside Rb3 is a potent neuroprotective compound; it can promote learning and memory. In this report, we found that the major ginsenoside in American ginseng leaves and berries was ginsenoside Rb3, while Rb3 only had limited amounts in the root of American ginseng and other species of the Panax genus. Ginsenoside Rb3 was quantified as 4.71% in American ginseng leaves and 5.35% in berries, suggesting that American ginseng leaves and berries are new sources of ginsenoside Rb3.

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Citations

Jun 27, 2006·Cancer Chemotherapy and Pharmacology·Han H AungChun-Su Yuan
Feb 6, 2013·Journal of Natural Medicines·Ha-Jeong KwonYong-Duk Park
Jan 25, 2011·Natural Product Reports·Lian-Wen QiChun-Su Yuan
Aug 22, 2007·The American Journal of Chinese Medicine·Chong-Zhi WangChun-Su Yuan
Dec 4, 2008·The American Journal of Chinese Medicine·Elaine LinChun-Su Yuan
Dec 4, 2008·The American Journal of Chinese Medicine·Chong-Zhi Wang, Chun-Su Yuan
Jul 20, 2012·The American Journal of Chinese Medicine·Chong-Zhi WangChun-Su Yuan
Nov 11, 2011·BMC Complementary and Alternative Medicine·Urszula DoughertyMarc Bissonnette
Oct 24, 2009·Chinese Medicine·Hongwei WangJingtian Xie
Sep 2, 2009·Biological & Pharmaceutical Bulletin·Jing-Tian XieChun-Su Yuan
Apr 22, 2011·Cancer Research and Treatment : Official Journal of Korean Cancer Association·Jing-Tian XieChun-Su Yuan
Dec 25, 2015·Artificial Cells, Nanomedicine, and Biotechnology·Priyanka SinghDeok Chun Yang
Aug 14, 2015·Journal of Chromatographic Science·Wei WuShuying Liu
Dec 9, 2015·Journal of Chromatography. a·Yaping WangLinfang Huang
Jul 22, 2014·Journal of Pharmaceutical and Biomedical Analysis·Chunhao YuChun-Su Yuan
Jun 25, 2016·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Mee Youn LeeChoong Hwan Lee
Mar 14, 2017·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Sha-Sha LiXiao-Jie Gong
Mar 24, 2016·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Ke-Ke LiXiao-Jie Gong
Dec 7, 2017·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Jae Won LeeDae Young Lee
Oct 18, 2014·Laboratory animal research·Won-Ho ShinSang-Joon Park
Sep 15, 2006·Journal of Separation Science·Petrus Hemström, Knut Irgum
Jun 1, 2007·Journal of Separation Science·Jian-Bo WanYi-Tao Wang
Dec 7, 2007·Phytochemical Analysis : PCA·Nadezhda AngelovaRob Verpoorte
Nov 6, 2015·Magnetic Resonance in Chemistry : MRC·Mark H NabuursChristopher W Kirby
Aug 22, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Jae Won LeeDae Young Lee
Oct 28, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Seong-Eun ParkHong-Seok Son
Nov 20, 2016·Artificial Cells, Nanomedicine, and Biotechnology·Priyanka SinghDeok Chun Yang
Jan 13, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Se Rin ChoiChoong Hwan Lee
Feb 27, 2021·Ecotoxicology and Environmental Safety·Jinjin JingPeng Xue
May 9, 2021·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Guang-Xuan ZhuShu-Qing Li

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