Saponins from Polygala japonica and their effects on a forced swimming test in mice

Journal of Natural Products
Ting-Zhao LiYun-Heng Shen

Abstract

Five new triterpenoid saponins, polygalasaponins E (1), F (2), G (3), H (4), and J (5), along with eight known ones (6-13), were isolated from the aerial parts of Polygala japonica. Their structures were established by chemical and spectroscopic means. Forced swimming tests on mice showed that saponins 1 and 4 significantly reduce the immobility status by 58.1% and 51.3% at a dosage of 100 mg/kg administrated orally once daily for 5 days, respectively.

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Citations

Feb 1, 2007·Journal of Natural Products·Shugeng CaoDavid G I Kingston
Jul 30, 2008·Natural Product Reports·Joseph D Connolly, Robert A Hill
Dec 2, 2006·Chemical & Pharmaceutical Bulletin·Honglan WangBoyang Yu
Apr 12, 2016·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Catharina Nucci-MartinsAdair R S Santos
May 19, 2009·Neuroscience Letters·Xiao-Hui XuCheng He
Oct 24, 2007·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·H WangB Yu
Jul 17, 2012·Fitoterapia·Chuangjun LiNaihong Chen
Oct 22, 2010·Chemistry & Biodiversity·Biswanath DindaYoshihiro Harigaya
Feb 22, 2012·Chemistry & Biodiversity·Luiz Carlos KleinValdir Cechinel Filho
Nov 26, 2019·Journal of Ethnopharmacology·Marie-Aleth Lacaille-DuboisAnne-Claire Mitaine-Offer
May 2, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Yu ZhouChong Sun

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