Saponins with neuroprotective effects from the roots of Pulsatilla cernua.

Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry
Jian-Yu LiuWen-Hao Fan

Abstract

Four new oleanene-type triterpenoid saponins together with six known saponins were isolated from the roots of Pulsatilla cernua and their structures were elucidated on the basis of spectroscopic data, including 2D NMR spectra and chemical evidence. Among these one of the aglycones (gypsogenin) is reported for the first time from this genus. Some of these compounds showed significant neuroprotective effects against the cytotoxicity induced by β-amyloid(25-35) (Aβ(25-35)) on human neuroblastoma SH-SY5Y cells.

References

Apr 1, 1986·Planta medica·M A DuboisH Wagner
Feb 26, 2000·Journal of Natural Products·Q ZhangS Zhao
Nov 8, 2005·Chemical & Pharmaceutical Bulletin·Seong-Cheol BangByung-Zun Ahn
Apr 4, 2007·Annals of the New York Academy of Sciences·Hyo Jin KimHyong Joo Lee
Nov 13, 2007·Journal of Asian Natural Products Research·Tun-Hai XuDong-Ming Xu
Mar 26, 2010·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Yajuan XuDongming Xu
Aug 31, 2010·Phytochemistry·Heejung YangSang Hyun Sung

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Citations

Jul 22, 2014·Archiv der Pharmazie·Lucie HellerRené Csuk
May 24, 2013·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Wei LiYoung Ho Kim
Dec 7, 2018·Natural Product Research·An-Dong WangYong-Nan Xu
May 22, 2021·Scientific Reports·Grażyna ŁaskaPremalatha Balachandran

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Methods Mentioned

BETA
NMR
column chromatography

Software Mentioned

MultiChro

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