PMID: 6987415Mar 1, 1980Paper

Saralasin test as a diagnostic and prognostic aid in renovascular hypertensive patients subjected to renal operation

The Journal of Urology
E F PoutasseJ P Franz

Abstract

A positive saralasin test in patients with angiographic evidence of renovascular disease and other positive functional tests gives further assurance that these patients will achieve normal or substantially reduced blood pressure postoperatively. In our experience with proved renovascular hypertension there was a 19 per cent incidence of falsely negative saralasin tests. Therefore, saralasin should not be used as the sole screening test in hypertensive patients suspected of having surgically correctable lesions. There is a direct correlation between elevated renin activity and a positive saralasin test. In some patients saralasin may be more sensitive than any other currently used test to detect overactivity of the renin-angiotensin system. This would determine those patients with technical errors in renin sampling and assays. Of the 16 patients (all normotensive) who had 6-month followup tests 5 had elevated peripheral renin activity, probably owing to furosemide stimulation. Of these 5 patients 2 had a positive postoperative saralasin test, raising the question of potential falsely positive responses in cases of essential hypertension and coincidental non-functional renal artery stenosis. Patients with high renin essential hyp...Continue Reading

References

May 22, 1976·Lancet·R FagardU Timmermans
Mar 19, 1977·Lancet·L S MarksJ J Kaufman
Mar 27, 1975·The New England Journal of Medicine·D H StreetenT G Dalakos
Jun 5, 1975·The New England Journal of Medicine·W A Pettinger, H C Mitchell
Jun 1, 1977·British Journal of Urology·L S MarksJ J Kaufman
Nov 1, 1977·Investigative Radiology·C J TegtmeyerH A Wellons
Sep 1, 1978·The Journal of Pediatrics·E B TraininT W AvRuskin
Dec 1, 1978·The Journal of Urology·J R WendelkenC B Windle
Jul 1, 1977·Annals of Internal Medicine·H M WilsonJ W Hollifield
Oct 9, 1976·British Medical Journal·R BeckerhoffW Siegenthaler
Aug 1, 1974·The New England Journal of Medicine·R E Keenan
Oct 1, 1973·The Journal of Urology·E F PoutasseA T Wan

Related Concepts

Angiotensin II, Val(5)-
Diastolic Blood Pressure
False Negative Reactions
Renal Hypertension
Hypertension, Renovascular
Kidney
Kidney Function Tests
Preprorenin

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