Sarcodon imbricatus polysaccharides protect against cyclophosphamide-induced immunosuppression via regulating Nrf2-mediated oxidative stress

International Journal of Biological Macromolecules
Xue WangDi Wang

Abstract

Sarcodon imbricatus, a rare medicinal and edible fungus, has various pharmacological bioactivities. The present study systematically investigated the protective effects of S. imbricatus polysaccharides (SIPS) against cyclophosphamide (CTX)-induced immunosuppression in Balb/c mice model. Compared with the CTX-induced immunosuppressive mice, the spleen and thymus indexes in the mice with 28-day SIPS orally administration were significantly increased, bodyweight loss was alleviated, and the natural killer (NK) cytotoxicity and the proliferative activities of lymphocytes were elevated. SIPS regulated the production of immunoglobulins including IgA, IgG and IgM in the serum and spleen. Notably, SIPS promoted the secretion of interleukin-2 (IL-2), IL-6, IL-10, IL-12 and interferon-γ (IFN-γ) of serum and spleen in CTX-induced immunosuppressive mice. Additionally, SIPS inhibited reactive oxygen species (ROS) levels and increased total antioxidant capacity, including superoxide dismutase (SOD), glutathione peroxidase (GSH-Px) and catalase (CAT) activities of spleen and thymus, as well as enhanced acid phosphatase (ACP) and lysozyme (LZM) levels of thymus in CTX-induced immunosuppressive mice. Histopathological analysis of spleen reveale...Continue Reading

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Citations

Apr 29, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Zaw Min ThuGiovanni Vidari
Apr 23, 2020·International Journal of Molecular Sciences·Xinling SongLe Jia
Nov 13, 2019·Free Radical Biology & Medicine·Xiao-Ting HuangSi-Yuan Tang
Feb 16, 2021·Immunopharmacology and Immunotoxicology·Yuexing ChangYun Deng

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