Sarcoid-like reactions in patients receiving modern melanoma treatment

Melanoma Research
Florentia DimitriouJoanna Mangana

Abstract

The development of cancer immunotherapy and targeted therapy has reached an important inflection point in the history of melanoma. Immune checkpoint inhibitors and kinase inhibitors are today's standard of care treatments in advanced melanoma patients. Treatment-related toxicities can be very intriguing and quite challenging. Sarcoidosis is a multisystemic granulomatous disease characterized by an aberrant immune response to unknown antigens, whereas sarcoid-like reactions (SLRs) refer to localized clinical features. We carried out a single-center observational study in patients with stage IIB-IV melanoma treated with BRAF/MEK inhibitors and immune checkpoint inhibitors. A description of the sarcoidosis-related manifestations was provided from patients' records. We observated eight cases of SLRs in a cohort of 200 patients. The clinical courses were characterized by a variety of symptoms, accompanied by cutaneous signs and extracutaneous manifestations such as bilateral, hilar lymphadenopathy. We identified a histologically granulomatous inflammation involving the skin, the lungs, and the lymph nodes. Two patients presented with cutaneous lesions only, and three patients had lung involvement only. Three patients achieved comple...Continue Reading

References

Mar 1, 1974·British Journal of Cancer·H Brincker, E Wilbek
Jan 25, 2006·The Journal of Experimental Medicine·Makoto MiyaraGuy Gorochov
Nov 23, 2007·The New England Journal of Medicine·Michael C IannuzziAlvin S Teirstein
Oct 4, 2008·Dermatology : International Journal for Clinical and Investigative Dermatology·A EckertL Thomas
Apr 15, 2009·Dermatology : International Journal for Clinical and Investigative Dermatology·Pascal SeveLuc Thomas
Jun 8, 2010·The New England Journal of Medicine·F Stephen HodiWalter J Urba
Nov 30, 2011·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Wouter V VogelChristian U Blank
May 2, 2012·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Grégoire BerthodOlivier Michielin
Jan 2, 2013·The European Respiratory Journal·Claire TissotGilles Devouassoux
Jan 12, 2013·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Dennie T FrederickJennifer A Wargo
Mar 5, 2013·The Oncologist·Mario E LacoutureAndrew K Joe
Jul 10, 2013·The British Journal of Dermatology·A AdamS Dalle
Sep 4, 2013·The European Respiratory Journal·Daniel FranzenErich W Russi
Oct 5, 2013·Lancet·Dominique ValeyreJoachim Müller-Quernheim
Oct 16, 2013·Journal of the American Academy of Dermatology·Ross B Reule, Jeffrey P North
Jun 1, 2014·The American Journal of Dermatopathology·Bonita ChoyPablo Fernández-Peñas
Jul 30, 2014·American Journal of Respiratory and Critical Care Medicine·Nicole A BraunWonder P Drake
Nov 18, 2014·The New England Journal of Medicine·Caroline RobertPaolo A Ascierto
Mar 11, 2015·Journal of the European Academy of Dermatology and Venereology : JEADV·R MössnerS Ugurel
Jun 18, 2015·Cancers·Bryce D Beutler, Philip R Cohen
Sep 1, 2015·Annals of Oncology : Official Journal of the European Society for Medical Oncology·R DummerUNKNOWN ESMO Guidelines Committee
Sep 16, 2015·Annals of Oncology : Official Journal of the European Society for Medical Oncology·J NaidooJ D Wolchok
Oct 9, 2015·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Morganna Freeman-KellerJeffrey Weber
Oct 10, 2015·Dermatology : International Journal for Clinical and Investigative Dermatology·Coralie LheureNicolas Dupin
Nov 1, 2015·Journal of Hematology & Oncology·Katy K Tsai, Adil I Daud
Mar 17, 2016·Journal for Immunotherapy of Cancer·Viktor H KoelzerKirsten D Mertz
Dec 30, 2016·Journal for Immunotherapy of Cancer·Joshua E ReussElizabeth M Gaughan

❮ Previous
Next ❯

Citations

Aug 24, 2018·Annals of Oncology : Official Journal of the European Society for Medical Oncology·A C TanA M Menzies
Jul 20, 2019·International Journal of Clinical Oncology·Pooja H RambhiaMeg R Gerstenblith
Apr 20, 2019·Journal of the European Academy of Dermatology and Venereology : JEADV·A AmouraF Cohen Aubart
May 23, 2019·Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG·Andrea Schmitt, Andreas Volz
Jun 12, 2019·Journal of Biomedical Science·Pleiades T InaokaJ Luis Espinoza
Dec 10, 2019·Rheumatology·Noha Abdel-Wahab, Maria E Suarez-Almazor
May 23, 2019·Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG·Andrea Schmitt, Andreas Volz
Apr 30, 2020·Journal of the European Academy of Dermatology and Venereology : JEADV·Ariadna Ortiz-BruguésCristina Carrera
Dec 20, 2019·Case Reports in Plastic Surgery & Hand Surgery·Hannah TrøstrupJette B Løvenwald
Mar 21, 2020·Current Treatment Options in Oncology·Subashini Sharon GnanendranAndrew Charles Miller
Mar 2, 2021·Immunotherapy·Sang T KimMaria E Suarez-Almazor
Apr 23, 2020·Journal of the American Academy of Dermatology·Anne Birgitte SimonsenClaus Zachariae
Sep 20, 2020·Annales de dermatologie et de vénéréologie·M PirothG Quéreux
May 28, 2019·La Revue de médecine interne·P SeveM Pavic
Apr 14, 2021·Journal of Investigative Medicine High Impact Case Reports·Hassaan YasinYehuda Lebowicz
Aug 17, 2021·Radiologic Clinics of North America·Nicola M Hughes, Heather A Jacene
Aug 29, 2021·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Noémie ChansonUNKNOWN Data Scientist

❮ Previous
Next ❯

Methods Mentioned

BETA
biopsies
biopsy
PCR

Clinical Trials Mentioned

NCT02752074
NCT02159066
NCT02060188

Related Concepts

Related Feeds

Cell Checkpoints & Regulators

Cell cycle checkpoints are a series of complex checkpoint mechanisms that detect DNA abnormalities and ensure that DNA replication and repair are complete before cell division. They are primarily regulated by cyclins, cyclin-dependent kinases, and the anaphase-promoting complex/cyclosome. Here is the latest research.

Cancer Vaccines

Cancer vaccines are vaccines that either treat existing cancer or prevent development of a cancer.

Anti-inflammatory Treatments

A drug or substance that reduces inflammation (redness, swelling, and pain) in the body. Anti-inflammatory agents block certain substances in the body that cause inflammation and swelling. Discover the latest research on anti-inflammatory treatments here