PMID: 9557788Apr 29, 1998Paper

Sarcoidal foreign-body granulomatous dermatitis associated with ophthalmic drops

The American Journal of Dermatopathology
J A CarlsonM C Mihm

Abstract

Sarcoidal granulomas are found in sarcoidosis and in reactions to foreign materials. We report the case of an 81-year-old woman with glaucoma who presented with multiple brown-black asymptomatic papules over the chin and involving nasal mucosa and columella of 1-year duration. Biopsy of the nasal mucosa and cutaneous papules showed sarcoidal granulomas associated with brown-black intracellular pigment within multinucleated giant cells. Electron-probe x-ray microanalysis demonstrated high sulfur content. Clinical studies showed no evidence of systemic sarcoidosis. Two of three ophthalmologic drops contained sodium bisulfite; bisulfite is known to cause allergic reactions. Although the exact substance causing the granulomatous reaction is unknown, the distribution of the lesions--nasal mucosa and columella (via the nasal lacrimal duct) and the underlying chin--implicate the eyedrops in the production of the pigmented granulomatous nodules.

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Citations

Oct 26, 2000·The American Journal of Dermatopathology·Y C KimL E Gibson
Jun 12, 2010·Chest·Valérie GounantJocelyne Fleury-Feith
Oct 2, 2012·Dermatologic Clinics·Luis RequenaHeinz Kutzner
Jul 6, 2015·Dermatologic Clinics·Ana M Molina-Ruiz, Luis Requena
Jul 6, 2015·Dermatologic Clinics·Roni P Dodiuk-Gad, Neil H Shear
Oct 28, 2020·American Journal of Clinical Dermatology·Nidhi ShahRoni P Dodiuk-Gad
Feb 19, 2021·Journal of Cutaneous Pathology·Diego Morales-Neira
Dec 7, 2007·La Revue de médecine interne·D Vital DurandH Rousset

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