Sarcoidosis activity: correlation of HRCT findings with those of 67Ga scanning, bronchoalveolar lavage, and serum angiotensin-converting enzyme assay

Journal of Computer Assisted Tomography
A N LeungP Grenier

Abstract

The objective of this study was to correlate the findings of sarcoidosis on high resolution CT (HRCT) with indexes of disease activity as measured with 67Ga scan, bronchoalveolar lavage (BAL), and serum angiotensin-converting enzyme (SACE) assay. Twenty-nine patients with proven sarcoidosis underwent HRCT scan, 67Ga scan, BAL, and SACE assay within a 1 month period. The extent of parenchymal involvement by nodules, consolidation, ground-glass attenuation, and linear opacities was quantified to the nearest 10% of surface area affected on the CT examination. Whole-lung gallium uptake was quantified and the percentage of BAL-recovered lymphocytes (BAL-%LC) and SACE levels obtained by chart review. CT scores of disease extent were correlated with measured indexes of activity using the Spearman rank correlation coefficient. The mean extent of nodules, consolidation, ground-glass attenuation, and linear opacities on HRCT images was 15.1 +/- 16.6, 1.6 +/- 4.0, 17.5 +/- 25.4, and 7.6 +/- 9.6%, respectively. The extent of nodules and consolidation correlated with the intensity of lung gallium uptake (r = 0.46, p < 0.02), BAL-%LC (r = 0.50, p < 0.01), and SACE levels (r = 0.38, p < 0.05). No significant correlation was found between exte...Continue Reading

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Citations

Oct 2, 2008·European Journal of Nuclear Medicine and Molecular Imaging·Alessandro AntonelliGiuliano Mariani
Aug 26, 1999·Current Opinion in Pulmonary Medicine·A G Wilcox
May 14, 2010·Journal of Thoracic Imaging·Baskaran SundaramElla A Kazerooni
Jun 14, 2000·AJR. American Journal of Roentgenology·M AbehseraM W Brauner
Aug 23, 2001·AJR. American Journal of Roentgenology·E A Kazerooni
Jan 9, 2014·European Radiology·Paolo SpagnoloDavid M Hansell
Nov 16, 2013·La Radiologia medica·Giuseppe RubiniAntonio Rotondo
Mar 3, 2015·Clinical Reviews in Allergy & Immunology·Mario SilvaNicola Sverzellati
Apr 13, 2012·Respiratory Medicine·Marc A Judson
Oct 4, 2012·Chest·Efstratios Panselinas, Marc A Judson
Jul 14, 2018·Current Opinion in Pulmonary Medicine·Vasileios KouranosSimon Walsh
Jun 18, 2003·European Radiology·Marjolein DrentJohny A Verschakelen
Oct 5, 2016·Thorax·Rachel BenamoreLing-Pei Ho

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