Sarcoidosis and IPF in the same patient-a coincidence, an association or a phenotype?

Respiratory Medicine
Bridget F CollinsGanesh Raghu

Abstract

Idiopathic Pulmonary Fibrosis (IPF) and Sarcoidosis are distinct clinical entities. Fibrotic disease in pulmonary sarcoidosis is typically upper lobe predominant. In IPF fibrosis is basilar and peripheral predominant [usual interstitial pneumonia (UIP) pattern]. Sarcoidosis and UIP have rarely been observed in the same patient. We sought to characterize patients manifesting both sarcoidosis and IPF and compare clinical features and survival to that of patients with "Lone-IPF" (IPF only) and pulmonary sarcoidosis with fibrosis in a non-UIP pattern. Patients were identified from a clinical database and data abstracted from medical records (1995-2016): 1) 25 patients with combined sarcoidosis and IPF (CSIPF) defined by clinical and histological features of sarcoidosis and HRCT features of possible or definite UIP or UIP by histopathology; 2) Randomly selected control patients during the same period: 28 Lone-IPF, 25 stage III/IV pulmonary sarcoidosis. The gender and race of patients with CSIPF and Lone-IPF patients were similar (68% male and 84% Caucasian), as were survival outcomes. Mean time from IPF diagnosis to death: 3.2 years CSIPF, 3.6 years Lone-IPF (log rank p value 0.49). Among patients with pulmonary sarcoidosis, mean ti...Continue Reading

Citations

Nov 30, 2018·The European Respiratory Journal·Coralynn Sack, Ganesh Raghu
Aug 15, 2019·Therapeutic Advances in Respiratory Disease·Shambhu Aryal, Steven D Nathan
Aug 3, 2020·Current Opinion in Pulmonary Medicine·Divya C Patel, Dominique Valeyre
Aug 11, 2020·Seminars in Respiratory and Critical Care Medicine·Rohit Gupta, Robert P Baughman
Aug 11, 2020·Seminars in Respiratory and Critical Care Medicine·Faisal ShaikhJoseph P Lynch
Mar 14, 2020·Respirology Case Reports·Michiru SawahataTetsuo Yamaguchi
Oct 4, 2019·European Respiratory Review : an Official Journal of the European Respiratory Society·Bridget F Collins, Ganesh Raghu
Oct 11, 2020·Journal of Clinical Medicine·Dominique Valeyre, Jean-François Bernaudin
Dec 12, 2018·Respiratory Medicine·Ramon ValentinDivya C Patel
May 25, 2021·Clinics in Chest Medicine·Bridget F Collins, Fabrizio Luppi
Apr 13, 2019·Respiratory Medicine·Bridget F Collins, Ganesh Raghu

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