Sarcoidosis Diagnostic Score: A Systematic Evaluation to Enhance the Diagnosis of Sarcoidosis

Chest
Alexandra N BickettR P Baughman

Abstract

The diagnosis of sarcoidosis is made by the combination of clinical features and biopsy results. The clinical features of sarcoidosis can be quite variable. We developed a Sarcoidosis Diagnostic Score (SDS) to summarize the clinical features of patients with possible sarcoidosis. Biopsy-confirmed patients with sarcoidosis seen during a 7-month period at the University of Cincinnati sarcoidosis clinic were prospectively identified. Patients with nonsarcoidosis seen at the same clinic were used as control patients. Using a modified World Association of Sarcoidosis and Other Granulomatous Disorders organ assessment instrument, we scored all patients for presence of biopsy, ≥1 highly probable symptom, and ≥1 at least probable symptom for each area. Two sarcoidosis scores were generated: SDS biopsy (with biopsy) and SDS clinical (without biopsy). The 980 evaluable patients were divided into two cohorts: an initial 600 patients (450 with biopsy-confirmed sarcoidosis, 150 control patients) to establish cutoff values for SDS biopsy and an SDS clinical and a validation cohort of 380 patients (103 biopsy-confirmed patients with sarcoidosis and 277 control patients). The best cutoff value for SDS biopsy was ≥ 6 (sensitivity, 99.3%; specif...Continue Reading

Citations

Jun 14, 2019·Current Opinion in Pulmonary Medicine·Marc A Judson
Nov 28, 2019·Journal of the European Academy of Dermatology and Venereology : JEADV·S A S van der BentT Rustemeyer
Mar 14, 2019·Current Opinion in Neurology·Mareye VoortmanRobert P Baughman
Aug 1, 2019·Current Opinion in Pulmonary Medicine·Marc A Judson
Mar 27, 2019·Respirology : Official Journal of the Asian Pacific Society of Respirology·Rocco TrisoliniDaniel A Culver
Jun 12, 2019·Journal of Biomedical Science·Pleiades T InaokaJ Luis Espinoza
May 6, 2020·Therapeutics and Clinical Risk Management·Thomas El JammalPascal Sève
Oct 13, 2020·ERJ Open Research·Clairelyne DupinVenerino Poletti
Feb 17, 2021·Respiratory Medicine·Arthur W HoltzclawSean A McKay
Nov 17, 2020·Frontiers in Medicine·Paolo CameliElena Bargagli
Apr 4, 2021·Cells·Pascal SèveThomas El Jammal
Feb 9, 2020·Respiratory Medicine and Research·F JenyD Valeyre
Jul 27, 2021·Frontiers in Medicine·Marc A Judson
Jul 8, 2021·Current Opinion in Pulmonary Medicine·Martina BonifaziElyse E Lower
Oct 5, 2021·Journal of Cosmetic Dermatology·S A S van der BentA Wolkerstorfer

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.