Sarcoidosis in Israel: Clinical Outcome Status, Organ Involvement, and Long-Term Follow-Up

Lung
Natalia MarkevitzDavid Shitrit

Abstract

Sarcoidosis is a chronic granulomatous inflammatory disease of unknown etiology with heterogeneous outcomes. This study reviewed the clinical outcome status (COS) and organ involvement of Israeli sarcoidosis patients during a five-year period. Further, we compared our results to the 'World Association of Sarcoidosis and Other Granulomatous Disease' (WASOG) COS and the 'A Case Control Etiologic Study of Sarcoidosis' (ACCESS) instruments in order to evaluate their relevance to the Israeli population. The retrospective study group consisted of 166 sarcoidosis patients for the period of 2010-2015. Data on demographic characteristics, presenting symptoms, co-morbidities, disease duration, lung function tests, treatment program, chest X-ray, and chest high-resolution computed tomography were collected. The median patient age was 62 ± 14, which was significantly higher than the WASOG and ACCESS cohorts (p < 0.0001), and the average disease duration was 9.8 ± 7.5 years. Resembling the ACCESS cohort, most patients were women (67.5%). The majority of patients suffered from constitutional symptoms (86%), as well as from respiratory symptoms (38.5%). Similarly to the ACCESS cohort, 91% of patients presented with lung involvement. However, ...Continue Reading

References

Aug 20, 1981·The New England Journal of Medicine·G W Hunninghake, R G Crystal
Dec 6, 2001·American Journal of Respiratory and Critical Care Medicine·R P BaughmanUNKNOWN Case Control Etiologic Study of Sarcoidosis (ACCESS) research group
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Aug 9, 2003·Current Opinion in Pulmonary Medicine·Violeta Mihailovic-VucinicJelica Videnovic-Ivanov
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May 24, 2016·Arthritis Care & Research·Patompong UngprasertEric L Matteson

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Citations

Dec 7, 2019·BMJ Case Reports·Pieter De MulderAn Vonck
May 22, 2021·Expert Review of Respiratory Medicine·Amira Yasmine BenmeloukaSheikh Mohammed Shariful Islam
May 30, 2021·European Journal of Internal Medicine·Raúl Fernández-RamónRicardo Blanco
Aug 18, 2021·Expert Review of Respiratory Medicine·Muhammad Junaid AkramMohammad Bilal Ashraf

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