Sarcoidosis mortality in Sweden: a population-based cohort study

The European Respiratory Journal
Marios RossidesElizabeth V Arkema

Abstract

We aimed to investigate sarcoidosis mortality in a large, population-based cohort, taking into account disease heterogeneity.Individuals with incident sarcoidosis (n=8207) were identified from the Swedish National Patient Register using International Classification of Disease codes (2003‒2013). In a subset, cases receiving treatment ±3 months from diagnosis were identified from the Prescribed Drug Register. Nonsarcoidosis comparators from the general population were matched to cases 10:1 on birth year, sex and county. Individuals were followed for all-cause death in the Cause of Death Register. Adjusted mortality rates, rate differences and hazard ratios (HRs) were estimated, stratifying by age, sex and treatment status.The mortality rate was 11.0 per 1000 person-years in sarcoidosis versus 6.7 in comparators (rate difference 2.7 per 1000 person-years). The HR for death was 1.61 (95% CI 1.47‒1.76), with no large variation by age or sex. For cases not receiving treatment within the first 3 months, the HR was 1.13 (95% CI 0.94‒1.35). The HR was 2.34 (95% CI 1.99‒2.75) for those receiving treatment.Individuals with sarcoidosis are at a higher risk of death compared to the general population. For the majority, the increased risk is...Continue Reading

References

Feb 1, 1997·American Journal of Epidemiology·B A RybickiM C Iannuzzi
Nov 11, 1999·American Journal of Respiratory and Critical Care Medicine·J AsklingA Ekbom
May 26, 2004·Computer Methods and Programs in Biomedicine·Stephen R Cole, Miguel A Hernán
Sep 7, 2004·American Journal of Respiratory and Critical Care Medicine·Lee S NewmanUNKNOWN ACCESS Research Group
Nov 11, 2008·American Journal of Respiratory and Critical Care Medicine·Johan Grunewald, Anders Eklund
Mar 6, 2010·American Journal of Respiratory and Critical Care Medicine·Cecilia CarlensJohan Askling
Jul 22, 2010·Epidemiologic Perspectives & Innovations : EP+I·Hendriek C Boshuizen, Edith Jm Feskens
Feb 19, 2011·American Journal of Respiratory and Critical Care Medicine·Jeffrey J SwigrisKevin K Brown
Jan 13, 2012·The International Journal of Tuberculosis and Lung Disease : the Official Journal of the International Union Against Tuberculosis and Lung Disease·M E Duncan, M J Goldacre
Sep 5, 2014·Chest·Mehdi MirsaeidiRobert P Baughman
Nov 2, 2014·The European Respiratory Journal·Kian Fan ChungUNKNOWN European Respiratory Society/American Thoracic Society Severe Asthma International Guidelines Task Force
Jan 5, 2016·Mayo Clinic Proceedings·Patompong UngprasertEric L Matteson
Jun 25, 2016·Annals of the Rheumatic Diseases·Yuqing ZhangHyon K Choi
Jul 30, 2016·The European Respiratory Journal·Elizabeth V ArkemaJohan Askling
Sep 24, 2016·The European Respiratory Journal·Yvan JamillouxPascal Seve
Feb 10, 2017·The European Respiratory Journal·Patompong UngprasertEric L Matteson
Apr 14, 2017·BMJ : British Medical Journal·Akbar K WaljeeBrahmajee K Nallamothu

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Citations

Apr 9, 2019·Circulation·Elisabetta PatornoSebastian Schneeweiss
Jul 26, 2019·Current Opinion in Pulmonary Medicine·Robert P Baughman, Athol Wells
Oct 19, 2019·Expert Review of Respiratory Medicine·Spyros A PapirisSofia Chatziioannou
Dec 24, 2019·Expert Review of Respiratory Medicine·Aman Pande, Daniel A Culver
Jul 14, 2020·Current Opinion in Pulmonary Medicine·Jelle R MiedemaPaolo Spagnolo
Jul 24, 2020·Current Opinion in Pulmonary Medicine·Florence Jeny, Jan C Grutters
May 6, 2020·The European Respiratory Journal·Marios RossidesElizabeth V Arkema
Aug 1, 2019·Current Opinion in Pulmonary Medicine·Robert P Baughman, Athol Wells
Jul 30, 2020·Journal of Clinical Medicine·Francesca PolverinoPaolo Spagnolo
Jul 6, 2019·Nature Reviews. Disease Primers·Johan GrunewaldJoachim Müller-Quernheim
Dec 18, 2020·Amyotrophic Lateral Sclerosis & Frontotemporal Degeneration·Can CuiFang Fang
Dec 4, 2020·Thorax·Muhunthan ThillaiAthol U Wells
Feb 20, 2019·Respiratory Medicine·Alicia K Gerke
May 23, 2020·Respiratory Medicine·Florence JenyDominique Valeyre
Apr 22, 2021·International Journal of Epidemiology·Julie M PetersenMatthew P Fox
May 29, 2021·ERJ Open Research·Joshua P EntropElizabeth V Arkema
May 22, 2020·La Presse médicale·Lucile SeséHilario Nunes
Jun 19, 2021·The European Respiratory Journal·Robert P BaughmanDaniel R Ouellette
Jan 12, 2022·Respirology : Official Journal of the Asian Pacific Society of Respirology·Melina Gade SikjaerAnders Løkke

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