Sarcoidosis: Role of non-tuberculosis mycobacteria and Mycobacterium tuberculosis

International Journal of Mycobacteriology
Esmaeil MortazPeter J Barnes

Abstract

Sarcoidosis is a granulomatous inflammatory disease that is induced by unknown antigen(s) in a genetically susceptible host. Although the direct link between Mycobacterium tuberculosis (MTB) infection and sarcoidosis can be excluded on the basis of current knowledge, non-infectious mechanisms may explain the causative role of mycobacterial antigens. Ever since sarcoidosis was first described, its relationship with tuberculosis (TB) has been under-investigated. Whereas some researchers consider sarcoidosis and TB as two examples of the same disease process, others have rejected mycobacteria as playing any causative role in sarcoidosis. Whether they are linked causally or not, clinical evidence makes a differential diagnosis between the two conditions very challenging, particularly in countries with high burden of TB. The present study analyzes the relationship between sarcoidosis and TB and its implications in clinical practice. The coincidence of TB and sarcoidosis and the higher incidence of mycobacterial DNA in biological samples of sarcoid patients have been reported by many authors. In addition, new evidence of a similarity in MTB phenotype in sarcoidosis is provided. Overall, these observations suggest that TB and sarcoido...Continue Reading

References

May 1, 1986·The American Journal of Medicine·C BennettH Golomb
Sep 1, 1995·Journal of the American Academy of Dermatology·R E EppsR E Van Scoy
Sep 1, 1996·Journal of Clinical Microbiology·F A el-ZaatariD Y Graham
Dec 31, 1997·Clinics in Chest Medicine·D R Moller
Sep 3, 1999·Journal of Cutaneous Pathology·N LiJ Bhawan
Jun 2, 2000·Virchows Archiv : an International Journal of Pathology·H KlemenH H Popper
May 8, 2001·American Journal of Clinical Pathology·J A IkonomopoulosC N Kittas
Apr 18, 2002·Annals of the Rheumatic Diseases·I LitinskyD Caspi
Aug 13, 2002·Current Opinion in Pulmonary Medicine·D Geraint James, Om P Sharma
Feb 18, 2003·Journal of Internal Medicine·R M du BoisP Cullinan
Mar 26, 2003·Seminars in Respiratory Infections·Rafael L PerezJesse Roman
Dec 3, 1960·British Medical Journal·J G SCADDING
Mar 16, 2005·Revue des maladies respiratoires·N GirardJ F Cordier
Jun 17, 2006·Chest·Stephen K Field, Robert L Cowie
Aug 24, 2006·Current Opinion in Pulmonary Medicine·Wonder Puryear Drake, Lee S Newman
Feb 6, 2007·American Journal of Respiratory and Critical Care Medicine·David E GriffithUNKNOWN Infectious Disease Society of America
Aug 9, 2007·Proceedings of the American Thoracic Society·Milton D Rossman, Mary Elizabeth Kreider
Mar 4, 2008·Clinical Genetics·G SmithS Prystowsky
Apr 23, 2008·Current Opinion in Pulmonary Medicine·Margaret M JohnsonJack P Leventhal
Jun 3, 2008·The European Respiratory Journal·P Sexton, A C Harrison
Jun 10, 2008·Clinics in Chest Medicine·Edward S Chen, David R Moller
Jun 10, 2008·Clinics in Chest Medicine·Joachim Müller-QuernheimStefan Schreiber
Jul 18, 2008·Journal of Clinical Microbiology·Joseph PapaparaskevasAthanassios Tsakris
Jul 31, 2008·Current Opinion in Pulmonary Medicine·Johan Grunewald
Feb 21, 2009·Journal of Applied Microbiology·J O Falkinham
Nov 20, 1875·British Medical Journal·J Hutchinson
Apr 5, 2011·The American Journal of Tropical Medicine and Hygiene·Ali A VelayatiMaryam F Sheikolslam
Nov 2, 2011·Oman Medical Journal·Farheen BadarSanna Kirmani
Jan 14, 2012·Journal of Infection in Developing Countries·Ali Akbar VelayatiNikolai Nikolaevich Poleschuyk
Feb 21, 2013·Frontiers in Immunology·John W J MoorePaul M Kaye
Apr 30, 2013·Frontiers in Immunology·Evelyn Guirado, Larry S Schlesinger
Jun 28, 2013·Journal of Ophthalmic Inflammation and Infection·Kalpana Babu
Dec 18, 2013·Frontiers in Immunology·Caroline E BroosBernt van den Blink
Feb 8, 2014·BMC Infectious Diseases·Marieke J van der WerfVibeke Ostergaard Thomsen
May 23, 2014·The American Journal of Case Reports·Wojciech J PiotrowskiSylwia Kwiatkowska
Sep 5, 2014·Journal of Clinical Immunology·Toshinao KawaiMasafumi Onodera

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Citations

Dec 20, 2018·International Journal of Environmental Research and Public Health·Janine SchoutenNicola Cherry
Mar 4, 2020·Journal of Cutaneous Pathology·Taro IsohisaNorito Katoh
Dec 3, 2016·Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft·J G Garweg
Jan 29, 2021·Frontiers in Medicine·Naureen Narula, Michael Iannuzzi
Mar 29, 2019·Paediatric Respiratory Reviews·Nadia NathanUNKNOWN Silicosis Research Group
Aug 8, 2021·Diagnostics·Thomas El JammalPascal Sève
Oct 1, 2021·Frontiers in Pediatrics·Richard KlausBärbel Lange-Sperandio

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