Sarcoidosis succumbs to antibiotics--implications for autoimmune disease

Autoimmunity Reviews
Trevor G Marshall, Frances E Marshall

Abstract

From time to time there have been reports of autoimmune disease succumbing to tetracycline antibiotics, but many have assumed this was due to coincidence, or to some ill-defined 'anti-inflammatory property' of the tetracyclines. But now the inflammation of sarcoidosis has succumbed to antibiotics in two independent studies. This review examines the cell wall deficient (antibiotic resistant) bacteria which have been found in tissue from patients with sarcoidosis. It examines how such bacteria can infect the phagocytes of the immune system, and how they may therefore be responsible for not only sarcoid inflammation, but also for other autoimmune disease. Proof positive of a bacterial pathogenesis for Sarcoidosis includes not only the demonstrated ability of these studies to put the disease into remission, but also the severity of Jarisch-Herxheimer shock resulting from endotoxin release as the microbes are killed. Studies delineating the hormone responsible for phagocyte differentiation in the Th1 immune response, 1,25-dihydroxyvitamin D, are discussed, and its utility as a marker of Th1 immune inflammation is reviewed. Finally, data showing that the behavior of this hormone is also aberrant in rheumatoid arthritis, systemic lupu...Continue Reading

References

Jul 1, 1991·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·E B MawerP J Holt
Nov 1, 1989·The British Journal of Ophthalmology·E WirostkoB Wirostko
Apr 13, 1989·The New England Journal of Medicine·H ReichelA W Norman
Jul 1, 1995·Current Opinion in Nephrology and Hypertension·K CasteelsC Mathieu
Feb 15, 2001·Archives of Dermatology·H BachelezL Dubertret
Apr 4, 2002·The Journal of Infectious Diseases·Kenneth NilssonOlle Lindquist
Jul 10, 2003·Lancet Neurology·Jun-ichi Kira
Sep 26, 2003·American Journal of Human Genetics·Milton D RossmanUNKNOWN ACCESS Group
Apr 1, 1950·British Medical Journal·J G Scadding

❮ Previous
Next ❯

Citations

Jul 16, 2009·Clinical Reviews in Allergy & Immunology·Merav LidarPnina Langevitz
Jan 13, 2006·Theoretical Biology & Medical Modelling·Trevor G MarshallFrances E Marshall
Mar 14, 2014·Expert Opinion on Drug Metabolism & Toxicology·Barbara GardellaArsenio Spinillo
Aug 12, 2009·Chest·Saurabh LodhaStephen Prystowsky
Jan 19, 2016·Journal of the American Academy of Dermatology·Vanessa L PascoeAlexandra Boer Kimball
Apr 18, 2012·Journal of the American Academy of Dermatology·Adele HaimovicStephen Prystowsky
Dec 23, 2008·La Presse médicale·Robin DhoteDominique Valeyre
Jun 20, 2008·Molecular Aspects of Medicine·Margherita T CantornaDanny Bruce
Dec 28, 2006·Journal of the American Academy of Dermatology·Christy Badgwell, Ted Rosen
Mar 9, 2005·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Shinji HagiwaraYasuhiko Tomino
Sep 18, 2009·Annals of the New York Academy of Sciences·Joyce C WaterhousePaul J Albert
Jan 18, 2008·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Trevor G Marshall
Oct 1, 2008·The Clinical Respiratory Journal·Claus Bo SvendsenKaren A Krogfelt
Apr 9, 2008·Dermatologic Therapy·Bruce H Thiers
Jul 6, 2015·Dermatologic Clinics·Miguel SanchezSteve Prystowsky
Apr 28, 2009·Autoimmunity Reviews·Paul J AlbertTrevor G Marshall
Apr 28, 2009·Autoimmunity Reviews·Amy D ProalTrevor Marshall
Apr 17, 2016·Medicina clínica·María Castellanos-González, María Remedios Picazo Talavera
Nov 6, 2015·Journal of Biochemical and Molecular Toxicology·A Di CerboG Terrazzano
Jun 26, 2013·Respiratory Investigation·Yoshinobu Eishi
Sep 7, 2016·Journal of Immunology Research·Gianandrea GuidettiGiuseppe Terrazzano
Nov 26, 2016·Journal of Neurosurgery·Jiro AkimotoYoshinobu Eishi
Jun 28, 2016·Journal of Autoimmunity·Jianguang JiKristina Sundquist
Jun 27, 2008·Drugs·Christy B Doherty, Ted Rosen
Nov 7, 2009·Acta Ophthalmologica·Barbara M Wirostko, William J Wirostko
Dec 16, 2017·The European Respiratory Journal·Alexandra ZimmermannAnnegret Fischer
Mar 10, 2020·IUBMB Life·Rasoul MirzaeiRasoul Yousefimashouf
Aug 11, 2020·Seminars in Respiratory and Critical Care Medicine·Ying Zhou, Elyse E Lower
Jun 12, 2019·Journal of Biomedical Science·Pleiades T InaokaJ Luis Espinoza
Oct 18, 2014·Journal of Neuro-ophthalmology : the Official Journal of the North American Neuro-Ophthalmology Society·Larry P Frohman
Feb 10, 2021·Pain Medicine : the Official Journal of the American Academy of Pain Medicine·Abhinav MohanEric Chang
May 1, 2021·International Journal of Environmental Research and Public Health·Todor I TodorovPrabath W B Nanayakkara
May 11, 2021·Internal Medicine·Yasuyuki TanakaHiroyuki Kokuryu

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antifungals

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.

Anti-inflammatory Treatments

A drug or substance that reduces inflammation (redness, swelling, and pain) in the body. Anti-inflammatory agents block certain substances in the body that cause inflammation and swelling. Discover the latest research on anti-inflammatory treatments here

Antifungals (ASM)

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.