Sarcoidosis triggered by interferon-Beta treatment of multiple sclerosis: a case report and focused literature review

Seminars in Arthritis and Rheumatism
Soumya D ChakravartyMary K Crow

Abstract

To report a rare case of sarcoidosis induced by chronic interferon-beta (a type I interferon) therapy of multiple sclerosis and to review previously reported cases. We describe a patient with a prior diagnosis of multiple sclerosis, who developed noncaseating granulomas in her skin and pulmonary lymph nodes, consistent with sarcoidosis, while being treated with recombinant interferon-beta. A retrospective review of the literature was performed using the PubMed database. In our patient, sarcoidosis developed after 3 years of continuous recombinant interferon-beta therapy, dosed 3 times a week. The patient presented with progressive dyspnea on exertion, diffuse arthralgias, low-grade fevers, with an acute onset of rash. The diagnosis of sarcoidosis was secured by finding typical, well-formed, noncaseating granulomas on skin and endobronchial biopsies, with other possible etiologies for granulomatous conditions excluded beforehand. Following the withdrawal of recombinant interferon-beta and a course of corticosteroids combined with disease-modifying anti-rheumatic drug therapy, the patient's clinical presentation resolved. Excluding ours, only 4 additional cases of sarcoidosis developing after interferon-beta therapy have been rep...Continue Reading

References

Aug 1, 1988·Annals of Neurology·U Traugott, P Lebon
Mar 26, 2002·Nature Reviews. Immunology·Amanda E I Proudfoot
Jul 14, 2006·Genes and Immunity·L G M van BaarsenC L Verweij
Oct 7, 2006·Journal of Clinical Rheumatology : Practical Reports on Rheumatic & Musculoskeletal Diseases·Mittie K DoyleJeanette H Magnus
Oct 21, 2006·Respirology : Official Journal of the Asian Pacific Society of Respirology·Kanako SugiyamaShigeru Kohno
Mar 8, 2007·Expert Review of Neurotherapeutics·Mathias Buttmann, Peter Rieckmann
Feb 25, 2009·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·A N Al-MasriG F Walter
Mar 18, 2009·International Immunopharmacology·Sandra R MirandolaLeonilda M B Santos
Oct 24, 2009·Current Opinion in Rheumatology·Winn Chatham
Jan 12, 2011·Immunology and Cell Biology·Joanna R Groom, Andrew D Luster
Feb 15, 2011·Arthritis Research & Therapy·Mary K Crow

❮ Previous
Next ❯

Citations

Dec 18, 2013·Journal of Medical Case Reports·Mohammad Ali SahraianAlireza Minagar
Mar 28, 2013·Case Reports in Hematology·Vadsala BaskaranAlfredo Addeo
Jul 7, 2015·International Journal of Molecular Sciences·Annette Kolb-MäurerMathias Mäurer
Sep 26, 2013·Joint, Bone, Spine : Revue Du Rhumatisme·Frank VerhoevenDaniel Wendling
Sep 3, 2013·Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG·Rebecca KörnerCornelia S L Müller
Sep 12, 2014·International Journal of Dermatology·Ana Carolina Dias Viana de AndradeMatheus Melo Pithon
Oct 14, 2014·Archivos de bronconeumología·Carmen Picón SerranoLuis Gorospe Sarasúa
Sep 2, 2016·American Journal of Respiratory and Critical Care Medicine·Sarah L N ClarkeAthimalaipet V Ramanan
Dec 14, 2017·QJM : Monthly Journal of the Association of Physicians·G CookeS C Donnelly
Nov 12, 2014·American Journal of Clinical Dermatology·Carolina Simunovic, Michi M Shinohara
Oct 16, 2019·Journal of Internal Medicine·F Cohen AubartB Lebrun-Vignes
Apr 6, 2018·Scientific Reports·Karla Cervantes-Gracia, Holger Husi
Oct 6, 2020·Frontiers in Pediatrics·Jinying LiZhongdong Du
Apr 27, 2018·Chest·Amit ChopraMarc A Judson
Aug 30, 2021·Journal of the Neurological Sciences·Thomas F Scott

❮ Previous
Next ❯

Related Concepts

Related Feeds

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.

Antimalarial Agents (ASM)

Antimalarial agents, also known as antimalarials, are designed to prevent or cure malaria. Discover the latest research on antimalarial agents here.

Astrocytes

Astrocytes are glial cells that support the blood-brain barrier, facilitate neurotransmission, provide nutrients to neurons, and help repair damaged nervous tissues. Here is the latest research.

Antimalarial Agents

Antimalarial agents, also known as antimalarials, are designed to prevent or cure malaria. Discover the latest research on antimalarial agents here.