Sarcolemmal and mitochondrial K(atp)channels mediate cardioprotection in chronically hypoxic hearts

Journal of Molecular and Cellular Cardiology
X KongJ E Baker

Abstract

X. Kong, J. S. Tweddell, G. J. Gross and J. E. Baker. Sarcolemmal and Mitochondrial K(ATP)Channels Mediate Cardioprotection in Chronically Hypoxic Hearts. Journal of Molecular and Cellular Cardiology (2001) 33, 1041-1045. Hypoxia from birth increases the resistance of the isolated neonatal heart to ischemia. We determined if increased resistance to ischemia was due to activation of sarcolemmal or mitochondrial K(ATP)channels. Rabbits (n=8/group) were raised from birth in a normoxic (F(I)O(2)=0.21) or hypoxic (F(I)O(2)=0.12) environment for 8-10 days and the heart perfused with Krebs-Henseleit bicarbonate buffer. A mitochondrial-selective K(ATP)channel blocker 5-hydroxydecanoate (5-HD) (300 micromol/l) or a sarcolemmal-selective K(ATP)channel blocker HMR 1098 (30 micromol/l) were added alone or in combination for 20 min prior to a global ischemic period of 30 min, followed by 35 min reperfusion. Recovery of ventricular developed pressure was higher in chronically hypoxic than normoxic hearts. 5-HD and HMR 1098 partially reduced the cardioprotective effect of chronic hypoxia, but had no effect in normoxic hearts. The combination of 5-HD and HMR 1098 abolished the cardioprotective effect of chronic hypoxia. We conclude that both s...Continue Reading

References

Apr 12, 1996·The Journal of Biological Chemistry·K D GarlidP A Schindler
Feb 1, 1997·Journal of Molecular and Cellular Cardiology·J E BakerZ J Bosnjak
Mar 9, 1999·Circulation·J E BakerG J Gross
Apr 11, 2000·Journal of Molecular and Cellular Cardiology·G J Grover, K D Garlid
Oct 29, 2000·Free Radical Biology & Medicine·Y ShiJ E Baker
Nov 25, 2000·Circulation Research·R Bolli

❮ Previous
Next ❯

Citations

Mar 18, 2004·Antioxidants & Redox Signaling·John E Baker
Nov 22, 2007·Journal of Cardiovascular Pharmacology·Yang ShiJohn E Baker
Mar 4, 2003·Journal of Cellular and Molecular Medicine·J N Peart, G J Gross
Sep 7, 2007·Medicine and Science in Sports and Exercise·Scott K PowersAndreas N Kavazis
Apr 7, 2007·Journal of Cardiovascular Medicine·Naranjan S DhallaSuresh K Gupta
Mar 16, 2011·Cardiology Research and Practice·Saeid Golbidi, Ismail Laher
Jun 16, 2012·Cardiology Research and Practice·Saeid Golbidi, Ismail Laher
Jan 3, 2014·Physiology·Scott K PowersJohn C Quindry
Sep 25, 2004·American Journal of Physiology. Heart and Circulatory Physiology·Yang ShiJohn E Baker
Jun 14, 2002·American Journal of Physiology. Heart and Circulatory Physiology·Marija Tonkovic-CapinJohn E Baker
Aug 14, 2003·American Journal of Physiology. Heart and Circulatory Physiology·Garrett J Gross, Jason N Peart
Feb 12, 2005·Journal of Applied Physiology·Pablo La Padula, Lidia E Costa
Nov 27, 2004·Experimental Biology and Medicine·Giuseppina MilanoMichele Samaja
May 16, 2002·Clinical and Experimental Pharmacology & Physiology·Stéphanie Garnier-RaveaudJean Verdetti
Sep 21, 2010·Molecular and Cellular Biochemistry·Markéta HlaváčkováOlga Nováková
Jan 15, 2008·Free Radical Biology & Medicine·Scott K PowersAndreas N Kavazis
Aug 25, 2009·Biochemical and Biophysical Research Communications·Jae-Hong KoJin Han

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.