Sarcoma-The standard-bearer in cancer discovery.

Critical Reviews in Oncology/hematology
Jared W PotterJared J Barrott

Abstract

Sarcoma is a rare tumor type that occurs most frequently in connective tissue. Despite its uncommon occurrence, sarcoma research has provided the means for groundbreaking research that has advanced our understanding of general cancer mechanisms. It is through sarcoma research that the pioneering efforts of cancer immunotherapy were explored, that we understand the inherent genetic nature of cancer mutations, and that we appreciate the subclassification of general cancer types to make more accurate prognoses. This review explores the brief history of sarcoma research and what sarcomas can still teach us about the future of cancer research, especially in regard to novel immunotherapy targets, the role of epigenetics in disease progression and chemoresistance, and the benefits of more focused clinical trials.

Citations

Aug 24, 2019·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Ian W FolkertMalay Haldar
Jun 14, 2020·Cells·Paula Martínez-DelgadoJavier Martin-Broto
May 16, 2020·Radiation Oncology·Gustavo R SarriaFrank A Giordano
Apr 30, 2020·International Journal of Molecular Sciences·Jordan L KohlmeyerDawn E Quelle
Jul 23, 2020·Molecular Diagnosis & Therapy·Aikaterini MastorakiEmmanouil Pikoulis
Oct 31, 2020·Frontiers in Oncology·Ya-Ling LiBing Song
Sep 17, 2021·Frontiers in Oncology·Alexander SeryakovMaxim Sorokin
Jan 8, 2022·The Journal of Applied Laboratory Medicine·Janet MartinWaliul I Khan

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