Sarcoma with MGA-NUTM1 fusion in the lung: an emerging entity

Virchows Archiv : an International Journal of Pathology
Taichiro GotoAkihiko Yoshida

Abstract

We here document a sarcoma with a recently reported MGA-NUTM1 fusion. A 49-year-old man presented with a nodule in the right lung, which grew to a giant mass in 5 years. The tumor showed uniform oval to spindle cell proliferation in a hypervascular stroma, associated with focal myxoid change and peculiar collagen deposition resembling an osteoid. The tumor showed an undifferentiated phenotype, including negativity for cytokeratin, although it was immunoreactive to BCOR and MUC4, and was initially suspected as BCOR-associated sarcoma. After complete resection, the tumor recurred in the mediastinal lymph node, and the patient died of the disease. RNA sequencing detected MGA (exon 22)-NUTM1 (exon 3), which was confirmed by reverse transcriptase-polymerase chain reaction, Sanger sequencing, fluorescence in situ hybridization, and NUT immunohistochemistry. Clinicopathological features of the present case were similar to some of the reported cases of MGA-NUTM1 sarcomas, suggesting the emergence of a distinct tumor subtype.

References

Mar 19, 2011·The American Journal of Surgical Pathology·Leona A DoyleJason L Hornick
Jun 19, 2012·Cancer Research·Alberto Cascón, Mercedes Robledo
Sep 18, 2012·The American Journal of Surgical Pathology·Leona A DoyleJason L Hornick
Jul 19, 2016·The American Journal of Surgical Pathology·Yu-Chien KaoCristina R Antonescu
Jan 28, 2017·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Vishwa Jeet AmatyaYukio Takeshima
Jun 19, 2018·The American Journal of Surgical Pathology·Brendan C DicksonJustin A Bishop
Oct 27, 2018·Pathology International·Christopher A French
Nov 9, 2018·The American Journal of Surgical Pathology·François Le LoarerFranck Tirode
Dec 16, 2018·Cold Spring Harbor Molecular Case Studies·Daniel DiolaitiNeerav Shukla
Feb 7, 2019·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Todd M StevensJulia A Bridge
Mar 14, 2019·The American Journal of Surgical Pathology·Pedram ArganiCristina R Antonescu

❮ Previous
Next ❯

Citations

Feb 16, 2020·Genes, Chromosomes & Cancer·Christopher R McEvoyOwen W J Prall
Sep 3, 2020·Laboratory Investigation; a Journal of Technical Methods and Pathology·Christopher R McEvoyOwen W J Prall
Jan 8, 2021·Virchows Archiv : an International Journal of Pathology·Kyriakos Chatzopoulos, Jennifer M Boland
Dec 29, 2020·Histopathology·Erna ForgóGregory W Charville
Mar 15, 2021·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Benjamin J Van TreeckAndrew L Folpe

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.