Sarcomatoid pilomatrix carcinoma

Journal of Cutaneous Pathology
Angel Fernandez-Flores, David S Cassarino

Abstract

Pilomatrix (pilomatrical) carcinoma is a rare cutaneous adnexal tumor with matrical differentiation and recurrent and metastatic potential. Sarcomatoid pilomatrix carcinoma is a rare variant which shows a sarcomatoid component intermingling with the epithelial one. There are only 4 cases previously published. We present an additional case on the hand of a 78 year-old man which appeared as a 6 mm hyperkeratotic, focally ulcerated plaque. A shave biopsy demonstrated a dermal infiltrative neoplasm, composed of markedly atypical-appearing basaloid cells with focal necrotic/ghost cells, as well as an intimately associated population of atypical oval to spindle-shaped cells. Both the epithelial and the sarcomatoid components expressed cytokeratins (CKs) AE1/AE3, CK 5/6 and CAM 5.2, as well as beta-catenin and LEF-1. The tumor failed to express CK7, CK20, S100, thyroid transcription factor 1 (TTF1), CDX2, prostate-specific antigen (PSA) and CD34. The tumor was completely excised with Mohs surgery, and there has been no recurrence in the 8 months of follow-up to date.

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Citations

Dec 26, 2018·Journal of Cutaneous Pathology·Daisuke Mori
Oct 22, 2019·The American Journal of Dermatopathology·Gregory A GatesScott W Binder
Apr 18, 2020·Journal of Cutaneous Pathology·Andrea SagginiLeo Schärer
May 8, 2020·The American Journal of Dermatopathology·Husain AlomranBrigitte Balme
Nov 16, 2021·Molecular and Clinical Oncology·Kazuki SuemuneSusumu Ikehara

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