Sarcomere imaging by quantum dots for the study of cardiac muscle physiology.

Journal of Biomedicine & Biotechnology
Fuyu Kobirumaki-ShimozawaNorio Fukuda

Abstract

We here review the use of quantum dots (QDs) for the imaging of sarcomeric movements in cardiac muscle. QDs are fluorescence substances (CdSe) that absorb photons and reemit photons at a different wavelength (depending on the size of the particle); they are efficient in generating long-lasting, narrow symmetric emission profiles, and hence useful in various types of imaging studies. Recently, we developed a novel system in which the length of a particular, single sarcomere in cardiomyocytes can be measured at ~30 nm precision. Moreover, our system enables accurate measurement of sarcomere length in the isolated heart. We propose that QDs are the ideal tool for the study of sarcomere dynamics during excitation-contraction coupling in healthy and diseased cardiac muscle.

References

Sep 1, 1985·Journal of Molecular and Cellular Cardiology·D G Allen, J C Kentish
Jun 1, 1982·Journal of Ultrastructure Research·T Fujimoto, K Ogawa
Nov 1, 1996·Pflügers Archiv : European journal of physiology·N FukudaS Ishiwata
Feb 27, 1999·Journal of Muscle Research and Cell Motility·N FukudaS Ishiwata
Jun 17, 1999·Pflügers Archiv : European journal of physiology·N Fukuda, S Ishiwata
Nov 2, 1999·Microscopy Research and Technique·C Soeller, M B Cannell
Jan 24, 2002·Nature·Donald M Bers
Jan 10, 2003·The Japanese Journal of Physiology·Nobuaki SaraiAkinori Noma
Sep 10, 2003·The Journal of Physiology·Norio FukudaHenk Granzier
Mar 26, 2004·Biophysical Journal·Naoto YagiFumihiko Kajiya
Aug 24, 2004·Current Vascular Pharmacology·Norio Fukuda, Henk Granzier
Feb 3, 2005·Pflügers Archiv : European journal of physiology·Norio FukudaHenk Granzier
Jul 7, 2005·Journal of Muscle Research and Cell Motility·Daisuke SasakiShin'ichi Ishiwata
Feb 3, 2006·Journal of Muscle Research and Cell Motility·Norio Fukuda, Henk L Granzier
Apr 4, 2006·Biochemical and Biophysical Research Communications·Daisuke SasakiShin'ichi Ishiwata
Feb 27, 2008·The Journal of General Physiology·Takako TeruiNorio Fukuda
May 15, 2008·The Journal of Physiological Sciences : JPS·Norio FukudaSatoshi Kurihara
Nov 18, 2009·The Journal of Biological Chemistry·Kohsuke GondaHideo Higuchi
Dec 8, 2009·Journal of Molecular and Cellular Cardiology·Norio FukudaSatoshi Kurihara
Mar 17, 2010·American Journal of Physiology. Heart and Circulatory Physiology·G BubP Kohl
May 4, 2010·Current Cardiology Reviews·Norio FukudaSatoshi Kurihara
Dec 18, 2010·Progress in Biophysics and Molecular Biology·Shin'ichi IshiwataNorio Fukuda
Dec 29, 2010·The Journal of General Physiology·Nicholas M P KingHenk Granzier
Jan 25, 2011·Journal of Molecular and Cellular Cardiology·Charles S Chung, Henk L Granzier
Jun 3, 2011·American Journal of Physiology. Cell Physiology·Peter BankheadJ Graham McGeown
Aug 5, 2011·American Journal of Physiology. Cell Physiology·Takahiro SerizawaNorio Fukuda

❮ Previous
Next ❯

Citations

May 3, 2014·The Journal of Physiological Sciences : JPS·Fuyu Kobirumaki-ShimozawaNorio Fukuda
Apr 24, 2019·The Journal of General Physiology·Shuya IshiiShin'ichi Ishiwata
Mar 1, 2015·Biophysics Reviews·Tatsuya KagemotoShin'ichi Ishiwata

❮ Previous
Next ❯

Methods Mentioned

BETA
X-ray

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.