PMID: 109116Apr 11, 1979

Sarcomere length effects on the Sr2+- and Ca2+-activation curves in skinned frog muscle fibres

Biochimica Et Biophysica Acta
D G Moisescu, R Thieleczek

Abstract

1. A procedure recently described to produce rapid changes in [Ca2+] and [Sr2+] within the whole cross-section of skinned muscle preparations (Moisescu, D.G. (1976) Nature 262, 610--613, and Moisescu, D.G. and Thieleczek, R. (1978) J. Physiol. 275, 241--262) has enabled us to obtain whole Ca2+- or Sr2+-activation curves at different sacromere lengths with the same preparation. 2. The maximal isometric force response was found to be very similar in Ca2+-and Sr2+-buffered solutions for otherwise identical conditions. 3. The change in sarcomere length between approx. 2.2 and 2.6 micron reversibly shifted both the Ca2+- and the Sr2+-activation curves by approx. 0.1 log units towards lower concentrations of the activator, without affecting their shape. However, the change in sarcomere length in the range above 2.6 micron did not have an effect upon the relative isometric force response-pCa (and -pSr) relationship. 4. All the Ca2+- and Sr2+-activation curves present a similar steepness and indicate that the relative isometric force increases from approx. 10 to 90% if the concentration of the activator is increased 3-fold. 5. The half time for force development in these experiments did not appear to be influenced by the length of the ...Continue Reading

References

Mar 22, 1975·Pflügers Archiv : European journal of physiology·Z TurekF Kreuzer
Jul 8, 1975·Biochimica Et Biophysica Acta·D G MoisescuA K Campbell
Dec 30, 1972·Journal of Molecular Biology·I Matsubara, G F Elliott

Citations

May 1, 1995·Pflügers Archiv : European journal of physiology·C CordonnierY Mounier
May 1, 1983·Pflügers Archiv : European journal of physiology·D G Stephenson, D A Williams
Nov 16, 1993·European Journal of Pharmacology·P SchiereckA Bavinck
Aug 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·P W BrandtM Kawai
Jun 1, 1982·The Journal of General Physiology·P W BrandtT Robinson
Oct 1, 1996·Clinical and Experimental Pharmacology & Physiology·D G Stephenson
Mar 13, 1986·Biochemical and Biophysical Research Communications·R Thieleczek, L M Heilmeyer
Nov 25, 2015·Muscle & Nerve·Natividad RodríGuez-ReyesWalter R Frontera
Jul 20, 2018·Journal of Applied Physiology·Graham D Lamb, D G Stephenson
Feb 10, 2007·The Journal of Biological Chemistry·Julie HedouB Bastide
Nov 27, 2002·Canadian Journal of Physiology and Pharmacology·D E Rassier, B R MacIntosh
Feb 1, 1990·Journal of Muscle Research and Cell Motility·G J Wilson, D G Stephenson
Apr 1, 1988·Journal of Muscle Research and Cell Motility·K HoriutiS Kurihara
May 8, 1999·Journal of Applied Physiology·D E RassierW Herzog
Mar 1, 1980·Journal of Muscle Research and Cell Motility·D G Stephenson, D A Williams
Aug 1, 1994·Journal of Muscle Research and Cell Motility·D A Smith, D G Stephenson
Oct 13, 2000·American Journal of Physiology. Cell Physiology·S K BortolottoG M Stephenson
Apr 1, 1988·The American Journal of Physiology·E L de BeerP Schiereck
Jan 1, 1981·The American Journal of Physiology·E W Stephenson

Related Concepts

Salientia
Calcium
Egtazic Acid Sodium Salt
Magnesium
Mathematics
Inotropism
Muscle
Rana esculenta
Strontium

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