Sarcomere length-tension relations of frog skinned muscle fibres at lengths above the optimum

The Journal of Physiology
F J Julian, R L Moss

Abstract

1. Single twitch fibres were dissected from anterior tibial muscles of the frog, Rana pipiens, and were then either chemically or mechanically skinned. Short segments of the skinned fibres were transferred to an experimental chamber and mounted between a force transducer and a stationary wire. 2. The average sarcomere length was determined from light photomicrographs of the segments obtained during activation and while relaxed. Activations were maximal, in solutions of pCa 5.49 and at 5 degrees C. Fibre segments having regions in which the striation pattern was highly non-uniform were rejected. 3. The relationship between tension and average sarcomere length was determined for sarcomere lengths between 2.1 and 3.8 micrometer. Tension always decreased when sarcomere length was increased above about 2.2 micrometer. Tension plotted against over-all average sarcomere length lay above data obtained from living fibres by Gordon, Huxley & Julian (1966a, b). 4. Good agreement with living fibre results was found when tension was plotted against the shortest average sarcomere length within a portion of the segment. 5. These findings indicate that sarcomere length non-uniformities greatly influence the shape of the sarcomere length-tensio...Continue Reading

Citations

Jun 1, 1988·Pflügers Archiv : European journal of physiology·W Herzog, H E ter Keurs
Aug 4, 2009·Journal of Biomechanics·Sampath K Gollapudi, David C Lin
Jul 3, 2013·Muscle & Nerve·Melinda J CromieScott L Delp
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Jan 1, 1987·Journal of Morphology·E Otten
Feb 26, 2020·The FEBS Journal·Arnab Nayak, Mamta Amrute-Nayak
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Aug 7, 2021·The Journal of Experimental Biology·Lomas S PersadRichard L Lieber

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