Sarcopenia and chronic liver diseases

Expert Review of Gastroenterology & Hepatology
Ching-Sheng Hsu, Jia-Horng Kao

Abstract

Sarcopenia is a syndrome characterized by progressive and generalized loss of skeletal muscle mass and strength, which is commonly associated with various chronic diseases, including chronic liver diseases. Growing lines of evidence indicate that sarcopenia not only correlates with the clinical outcomes and survival of patients undergoing liver transplant, but also serves as a prognostic factor for candidates of liver transplantation and patients with hepatocellular carcinoma. Areas covered: In this review, we conducted a narrative review and search of literature from PubMed, Ovid MEDLINE, and the Cochrane Library database up to August 2018. Studies relevant to the emerging data of sarcopenia and chronic liver diseases were examined and discussed. Expert commentary: Although sarcopenia has been shown to play a vital role in the outcomes of cirrhotic patients with or without liver transplant, its impact on non-cirrhotic patients remains unclear and deserves future research efforts. To develop an effective and practical measurement of sarcopenia has become an urgent issue in the management of patients with chronic liver diseases. HCC: hepatocellular carcinoma; L3SMI: third lumbar vertebra skeletal muscle index; NAFLD: nonalcoholi...Continue Reading

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Citations

Jan 16, 2020·Journal of Clinical Medicine·Hiroki NishikawaShuhei Nishiguchi
Aug 20, 2020·Expert Review of Gastroenterology & Hepatology·Tiziana Fernández-MinconeFrancisco Barrera
Aug 5, 2020·Journal of Gastroenterology·Giovanni MarascoAntonio Colecchia
Jun 4, 2020·International Journal of Molecular Sciences·Francisco AguirreClaudio Cabello-Verrugio
Sep 25, 2020·Transplant International : Official Journal of the European Society for Organ Transplantation·Dmitry RozenbergSunita Mathur
Jan 16, 2021·Journal of Clinical and Translational Hepatology·Sarah Altajar, Gyorgy Baffy
Nov 6, 2020·Oxidative Medicine and Cellular Longevity·Andrea GonzalezClaudio Cabello-Verrugio
Oct 30, 2020·International Journal of Molecular Sciences·Johanna AbrigoClaudio Cabello-Verrugio
Mar 28, 2021·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Hiroki NishikawaHiroko Iijima
Apr 10, 2021·World Journal of Gastroenterology : WJG·Rahul ChaudhariJoseph M Pappachan
Jul 22, 2021·Arquivos De Gastroenterologia·Nida JavaidMaryam Hameeda
Jul 17, 2021·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Nahoko KikuchiWasaburo Koizumi
Aug 28, 2021·World Journal of Gastroenterology : WJG·Andrej Hari
Sep 21, 2021·Expert Opinion on Pharmacotherapy·Ching-Sheng Hsu, Jia-Horng Kao
Nov 24, 2021·Journal of Cachexia, Sarcopenia and Muscle·Sung-Eun Kim, Dong Joon Kim
Jan 15, 2022·Calcified Tissue International·Julie A PascoMark A Kotowicz

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