Sarcopenia and ovarian cancer survival: a systematic review and meta-analysis

Journal of Cachexia, Sarcopenia and Muscle
Jorne UbachsToon Van Gorp

Abstract

Sarcopenia is the loss of skeletal muscle mass and function that occurs with advancing age and certain diseases. It is thought to have a negative impact on survival in cancer patients. Routine computed tomography imaging is often used to quantify skeletal muscle in cancer patients. Sarcopenia is defined by a low skeletal muscle index (SMI). Skeletal muscle radiation attenuation (SMRA) is used to define muscle quality. The primary aim of this meta-analysis was to study the association between sarcopenia or SMRA and overall survival (OS) or complications in patients with ovarian cancer. Medline, Embase, CINAHL, and PEDro databases were searched from inception to 15 February 2019. Studies evaluating the prognostic effect of SMI and SMRA on ovarian cancer survival or surgical complications were included. Risk of bias and study quality were evaluated with the Quality in Prognosis Studies Instrument (QUIPS) according to the modified Grading of Recommendations Assessment, Development, and Evaluation (GRADE) framework. The search strategy yielded 4262 hits in all four databases combined. Ten and eight studies were included for qualitative and quantitative analysis, respectively. Meta-analysis revealed a significant association between ...Continue Reading

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Citations

Dec 12, 2019·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Yong LiAiqin He
Jan 31, 2020·Journal of Cachexia, Sarcopenia and Muscle·Chueh-Yi HuangJie Lee
Apr 4, 2020·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Emanuele RinninellaMaria Cristina Mele
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Feb 6, 2021·Journal of Cachexia, Sarcopenia and Muscle·Jalid SehouliMelisa Guelhan Inci
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Jan 9, 2021·Journal of Ovarian Research·Xiaolei YuanPeiling Li
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Methods Mentioned

BETA
X‐ray

Software Mentioned

Grading of Recommendations Assessment , Development , and Eval...
QUIPS
RevMan
OvidSP
Review Manager

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