Sarcopenia, but not visceral fat amount, is a risk factor of postoperative complications after major hepatectomy

International Journal of Clinical Oncology
Takaaki HigashiHideo Baba

Abstract

Major hepatectomy is associated with significant morbidity and mortality rates, particularly in patients aged more than 70 years. This study assessed whether physical indicators, such as sarcopenia and visceral fat amount, could predict morbidity and mortality after major hepatectomy. The study enrolled 144 patients who underwent curative major hepatectomy. Skeletal muscle and visceral fat amount at the third lumbar vertebra (L3) in the inferior direction were quantified using enhanced computed tomography scans. The patients were divided into two subgroups, with and without sarcopenia, based on median skeletal muscle mass in men and women (43.2 cm(2)/m(2) in men; 35.3 cm(2)/m(2) in women). The study included 108 men and 36 women, with median skeletal muscle tissue of 43.2 and 35.3 cm(2)/m(2), respectively. The mortality rate was significantly higher in patients with than without sarcopenia [seven cases (9.7 %), one case (1.4 %), respectively; P = 0.021], whereas liver-related morbidity and mortality rates were similar. In patients aged >70 years, the morbidity, liver dysfunction-related morbidity, and mortality rates were significantly higher in patients with than without sarcopenia (P < 0.05 each). In contrast, surgical outcom...Continue Reading

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Nov 28, 2015·International Journal of Clinical Oncology·Umit Cintosun, Battal Altun
Aug 3, 2016·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Hiroki NishikawaShuhei Nishiguchi
Dec 2, 2017·Journal of Gastroenterology and Hepatology·Atsushi HiraokaKojiro Michitaka
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Feb 17, 2019·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Atsushi HiraokaKojiro Michitaka
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