Sarcopenia in juvenile localized scleroderma: new insights on deep involvement

European Radiology
Silvia Karem Janet Flores QuispeChiara Giraudo

Abstract

Juvenile localized scleroderma (JLS) is a rare chronic autoimmune disease which can also affect bones and muscles. Nevertheless, muscle loss was not previously investigated in patients with JLS. Thus, the aim of this study was to retrospectively evaluate deep involvement and assess and quantify sarcopenia in JLS patients using magnetic resonance imaging (MRI). Fourteen children with JLS (nine females, mean age ± SD, 7.1 ± 3.6 years) referring to our tertiary center from January 2012 to January 2018 who underwent at least one MRI examination including axial T1-weighted and short tau inversion recovery images were included. Two readers assessed in consensus superficial and deep involvement. Muscle edema, muscle fatty infiltration, and sarcopenia were independently scored (absent, moderate, or severe) and the Cohen's kappa coefficient computed. Skin perimeter, subcutaneous area, muscle area, and muscle volume were independently measured using the contralateral unaffected extremity as reference (paired Student's t test, p < 0.05). The intraclass correlation coefficient (ICC) was used to investigate the reliability of the measurements. All patients showed superficial involvement with subcutaneous fat atrophy being the most common fi...Continue Reading

References

Sep 6, 2005·Arthritis and Rheumatism·Francesco ZulianUNKNOWN Juvenile Scleroderma Working Group of the Pediatric Rheumatology European Society (PRES)
Dec 22, 2005·Rheumatology·F ZulianUNKNOWN Juvenile Scleroderma Working Group of the Pediatric Rheumatology European Society (PRES)
Oct 21, 2006·Current Opinion in Rheumatology·Ronald M Laxer, Francesco Zulian
May 4, 2007·The British Journal of Ophthalmology·Maria Elisabetta ZanninUNKNOWN Juvenile Scleroderma Working Group of the Pediatric Rheumatology European Society (PRES)
Dec 21, 2007·AJR. American Journal of Roentgenology·Marius HorgerJan Fritz
Feb 21, 2009·Journal of Neurology, Neurosurgery, and Psychiatry·B C BöckleN T Sepp
Jan 22, 2010·International Journal of Clinical Practice·N S TekinN Onsun
Mar 2, 2010·Arthritis Care & Research·Ariane L HerrickEileen M Baildam
Jan 18, 2011·Journal of the American Academy of Dermatology·Nicole Fett, Victoria P Werth
Jun 23, 2011·Radiology·Stefan SchanzMarius Horger
May 9, 2012·Pediatric Clinics of North America·Kathryn S Torok
Apr 9, 2013·Journal of the American Academy of Dermatology·Christina E Kelsey, Kathryn S Torok
Feb 27, 2014·Neuromuscular Disorders : NMD·Saša A ZivkovićThomas A Medsger
Feb 13, 2015·Anais Brasileiros De Dermatologia·Mariana Figueiroa Careta, Ricardo Romiti
Dec 13, 2016·International Journal of Dermatology·Maria T Garcia-RomeroElena Pope
Jan 17, 2017·Pediatric Radiology·Eric P EutslerLauren W Averill
Dec 14, 2017·International Journal of Hematology·Daisuke SuzukiKunihiko Kobayashi
Mar 15, 2018·Journal of the American Academy of Dermatology·Sakeen W KashemSheilagh M Maguiness
May 19, 2018·Best Practice & Research. Clinical Rheumatology·Francesco Zulian
Nov 14, 2018·European Radiology·Luca Maria Sconfienza
Jul 23, 2019·JPEN. Journal of Parenteral and Enteral Nutrition·Poh Hwa OoiDiana R Mager
Dec 14, 2019·European Radiology·Domenico AlbanoLuca Maria Sconfienza

❮ Previous
Next ❯

Citations

Jul 17, 2021·Skeletal Radiology·Wilfred ManzanoRobert D Boutin

❮ Previous
Next ❯

Related Concepts

Related Feeds

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.

Related Papers

Clinical Medicine : Journal of the Royal College of Physicians of London
Alfonso J Cruz-Jentoft, Francesco Landi
BMJ : British Medical Journal
Avan Aihie Sayer
World Journal of Pediatrics : WJP
Suzanne C Li, Rong-Jun Zheng
© 2021 Meta ULC. All rights reserved