Sarcopenia Is Associated With Lower Skeletal Muscle Capillarization and Exercise Capacity in Older Adults

The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
Steven J PriorAndrew P Goldberg

Abstract

Skeletal muscle capillary rarefaction limits the transcapillary transport of nutrients and oxygen to muscle and may contribute to sarcopenia and functional impairment in older adults. We tested the hypothesis that skeletal muscle capillarization and exercise capacity (VO2max) are lower in sarcopenic than in nonsarcopenic older adults and that the degree of sarcopenia is related to lower skeletal muscle capillarization. Body composition, VO2max, and vastus lateralis capillarization were determined in 76 middle-aged and older men and women (age = 61±1 years, body mass index [BMI] = 30.7±0.5kg/m(2) [mean ± SEM]). Participants were classified as sarcopenic if appendicular lean mass divided by BMI (ALMBMI) was less than 0.789 for men or less than 0.512 for women. Sarcopenic subjects (ALMBMI = 0.65±0.04, n = 16) had 20% lower capillary-to-fiber ratio, as well as 13% and 15% lower VO2max expressed as mL/kg/min or L/min, respectively, compared with sex-, race-, and age-matched participants without sarcopenia (ALMBMI = 0.81±0.05, n = 16; p < .05). In all 76 subjects, ALMBMI, thigh muscle cross-sectional area, and VO2max correlated directly with capillarization (r = .30-.37, p ≤ .05), after accounting for age, sex, and race. These findin...Continue Reading

References

May 1, 1992·Journal of Applied Physiology·A R CogganJ O Holloszy
Jun 1, 1997·Journal of Applied Physiology·J V HennesseyD B MacLean
Jan 28, 1998·Arteriosclerosis, Thrombosis, and Vascular Biology·H TanakaD R Seals
Jan 30, 1999·Journal of Molecular and Cellular Cardiology·G VescovoL Dalla Libera
Mar 17, 1999·International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity·A S Ryan, B J Nicklas
Apr 6, 2000·Journal of Applied Physiology·W R FronteraR Roubenoff
Sep 12, 2000·Circulation·H TanakaD R Seals
Apr 3, 2001·The Journal of Laboratory and Clinical Medicine·J E MorleyK S Nair
Oct 4, 2002·Muscle & Nerve·Michelle M PorterJan Lexell
Nov 29, 2002·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Michele Iannuzzi-SucichAnne M Kenny
Apr 23, 2008·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Andrea Z LaCroixUNKNOWN Women's Health Initiative
Oct 15, 2008·Aging Clinical and Experimental Research·Barbara J NicklasWilliam E Kraus
Sep 11, 2009·The American Journal of Clinical Nutrition·Emilie A WilkesMichael J Rennie
Jun 29, 2010·Current Opinion in Lipidology·Guru M Krishnan, Paul D Thompson
Apr 12, 2011·Age·Angela Marie AbbatecolaUNKNOWN Health ABC study
Nov 15, 2011·Pharmacology & Therapeutics·Noboru Toda
Feb 11, 2012·American Journal of Physiology. Cell Physiology·Jeff R S LeiterJudy E Anderson
Aug 21, 2012·Nutrition, Metabolism, and Cardiovascular Diseases : NMCD·K L Timmerman, E Volpi
Aug 21, 2012·Maturitas·Hans Degens, Marko T Korhonen
Jan 15, 2013·Age and Ageing·Avan Aihie SayerMiranda D Grounds
Feb 5, 2013·Trends in Endocrinology and Metabolism : TEM·Matthew L JohnsonK Sreekumaran Nair
Sep 24, 2013·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·A MithalUNKNOWN IOF CSA Nutrition Working Group
Sep 28, 2013·Arteriosclerosis, Thrombosis, and Vascular Biology·Mariangela PalladinoRoberto Pola
Nov 20, 2013·Aging Cell·Huijuan WangDaniel Béchet
Jan 24, 2014·Geriatrics & Gerontology International·Ricardo Aurélio Carvalho SampaioHidenori Arai
Mar 1, 2014·Journal of Applied Physiology·Bart B L GroenLuc J C van Loon
Apr 17, 2014·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Peggy M CawthonDawn E Alley

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Citations

Sep 28, 2016·Wiener klinische Wochenschrift·John E Morley
Apr 14, 2018·Exercise and Sport Sciences Reviews·Rian Q Landers-Ramos, Steven J Prior
Aug 24, 2018·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Céline DalleCécile Gladine
Jun 6, 2019·Journal of Muscle Research and Cell Motility·Paul Hendrickse, Hans Degens
May 31, 2018·The Journal of Clinical Endocrinology and Metabolism·Tinna TraustadóttirThomas W Storer
Feb 6, 2020·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·Bjorn T TamSylvia Santosa
Aug 23, 2017·Scientific Reports·Qingfeng ChengQifu Li
Nov 28, 2018·BMC Research Notes·Daisy WilsonElizabeth Sapey
Dec 21, 2018·The Journal of Nutrition, Health & Aging·K-I KimC-H Kim
Jun 4, 2020·International Journal of Molecular Sciences·Emiliana GiacomelloLuana Toniolo
May 16, 2020·Frontiers in Cell and Developmental Biology·Weiqi HongXiawei Wei
May 26, 2020·International Journal of Food Sciences and Nutrition·Luana TonioloEmiliana Giacomello
Jan 5, 2017·Journal of Nutrition and Metabolism·D SaulS Sehmisch
Sep 18, 2020·International Journal of Molecular Sciences·Stefania FochiMaria Grazia Romanelli
Jan 4, 2021·Cardiovascular and Interventional Radiology·Abdullah O AleneziGraham Roche-Nagle
Nov 16, 2020·Mechanisms of Ageing and Development·Yuxiao GuoMathew Piasecki
Nov 19, 2020·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Alistaire D RuggieroKylie Kavanagh
Sep 16, 2020·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Chih-Chien LinSung-Ling Yeh
Apr 20, 2021·Laryngoscope Investigative Otolaryngology·Alexander Joseph JonesAvinash V Mantravadi
Dec 3, 2021·ESC Heart Failure·Julien RegameyRoger Hullin

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