Sarcopenia Is Independently Associated with the Degree of Liver Fibrosis in Patients with Type 2 Diabetes Mellitus.

Gut and Liver
Min Je SungSeung Up Kim

Abstract

Sarcopenia is associated with liver fibrosis in patients with nonalcoholic fatty liver disease and chronic hepatitis B. We investigated the association between sarcopenia and hepatic fibrotic burden in patients with type 2 diabetes mellitus (T2DM). Patients with T2DM who had received a comprehensive medical health checkup were recruited. Muscle mass was assessed using computed tomography. Fibrotic burden was assessed using the fibrosis-4 index (FIB-4). The study population was divided by quartile stratification of the lumbar skeletal muscle index (LSMI). Among 309 patients with T2DM, 75 (24.3%) had sarcopenia. These patients were significantly older and had higher FIB-4, whereas they had significantly lower body mass index (BMI) and LSMI than patients without sarcopenia (all p<0.05). The LSMI showed a significant negative correlation with the FIB-4 when analyzed in terms of quartile stratification (p=0.003). Multivariate analysis showed that female sex and higher BMI were independently associated with a reduced risk of sarcopenia (odds ratio [OR], 0.388; 95% confidence interval [CI], 0.199 to 0.755 and OR, 0.704; 95% CI, 0.618 to 0.801; all p<0.05), whereas a higher FIB- 4 was independently associated with an increased risk of ...Continue Reading

References

Nov 26, 1999·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·P AnguloK D Lindor
Mar 30, 2007·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Paul AnguloChristopher P Day
Jun 15, 2007·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Anaïs Vallet-PichardStanislas Pol
Apr 25, 2009·The Journal of Nutrition, Health & Aging·W C Stephen, I Janssen
Nov 17, 2009·Current Opinion in Clinical Nutrition and Metabolic Care·Alfonso J Cruz-JentoftJean-Pierre Michel
Apr 16, 2010·Age and Ageing·Alfonso J Cruz-JentoftUNKNOWN European Working Group on Sarcopenia in Older People
May 26, 2011·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Takumi KawaguchiMichio Sata
Oct 20, 2012·Archives of Gerontology and Geriatrics·Ji-Youn ChungYong-Jae Lee
Sep 3, 2013·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Ho Cheol HongKyung Mook Choi
Sep 14, 2013·Liver International : Official Journal of the International Association for the Study of the Liver·Young Eun ChonKwang-Hyub Han
Dec 21, 2013·Diabetes Care·UNKNOWN American Diabetes Association
Dec 21, 2013·Diabetes Care·UNKNOWN American Diabetes Association
Jan 28, 2014·Journal of the American Medical Directors Association·Liang-Kung ChenHidenori Arai
Mar 14, 2014·The Lancet. Diabetes & Endocrinology· The Lancet Diabetes Endocrinology
Sep 24, 2014·Current Diabetes Reviews·Michela CetroneDomenico Tricarico
Dec 3, 2014·Nutrition·Tatsunori HanaiHisataka Moriwaki
Jun 3, 2015·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Shinji ItohYoshihiko Maehara
Jun 10, 2015·JAMA : the Journal of the American Medical Association·Mary E Rinella
Dec 8, 2015·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Yong-ho LeeKwang-Hyub Han
Aug 30, 2016·Journal of the American Medical Directors Association·Anthony Liccini, Theodore K Malmstrom
Sep 1, 2016·Pharmacology·Lluis CampinsMateu Serra-Prat
Aug 5, 2017·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Rahima A BhanjiKymberly D Watt
Oct 11, 2017·Journal of Gastroenterology and Hepatology·Eun Yeong ChoeZobair M Younossi

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Citations

Nov 10, 2020·Liver International : Official Journal of the International Association for the Study of the Liver·Yun-Cheng HsiehWon Kim

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Methods Mentioned

BETA
X-ray

Software Mentioned

SPSS
Aquarius Intuition Viewer

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