Sarcopenia is poor prognostic factor in older patients with locally advanced rectal cancer who received preoperative or postoperative chemoradiotherapy

Medicine
Song Ee ParkJin Hwa Choi

Abstract

Sarcopenia is associated with low muscle mass and low physical performance. Here, we performed to evaluate the sarcopenia as prognostic factor and treatment outcomes in older patients with locally advanced rectal cancer (LARC) who received preoperative or postoperative chemoradiotherapy (CRT).LARC patients aged ≥65 years who received either preoperative or postoperative CRT were analyzed retrospectively. Preoperative or postoperative CRT consisted of 50.4 Gy and fluoropyrimidine. Surgery was performed at 6 weeks after CRT completion. Postoperative CRT was performed at 4 weeks after surgery. One month after surgery or CRT, adjuvant chemotherapy was given. Overall survival (OS) and disease free survival (DFS), local recurrence (LR), and prognostic factor were evaluated.Thirty patients received preoperative CRT and 35 patients received postoperative CRT. Five-year OS rate, 5-year DFS rate, or 5-year LR rate was not significantly different between preoperative and postoperative CRT groups (69.0%, 58.5%, and 3.4% vs 73.6%, 67.9%, and 6.9%, P = .56, P = .37, and P = .77, respectively). Age, sex, stage, CEA level, or timing of CRT did not affect OS. However, 5-year OS rate of patients with sarcopenia was significantly lower than those...Continue Reading

References

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Citations

Mar 15, 2019·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·A GökyerB Erdoğan
Jun 27, 2019·Nutrition in Clinical Practice : Official Publication of the American Society for Parenteral and Enteral Nutrition·Eun Young KimIn Kyu Lee
Dec 5, 2019·Cancer Imaging : the Official Publication of the International Cancer Imaging Society·Huaiying SuLijing Shi
Mar 7, 2020·Journal of Surgical Oncology·Katherine BingmerEmily Steinhagen
Nov 27, 2019·Cancers·Richard F DunneSupriya G Mohile
Dec 23, 2019·Endocrine·Haruhiko YamazakiKouichi Ito
Apr 28, 2020·World Journal of Clinical Cases·Omar Vergara-FernandezNoel Salgado-Nesme

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Methods Mentioned

BETA
surgical resection

Software Mentioned

Statistical Package for Social Sciences ( SPSS )

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