Sarcopenia, the depletion of muscle mass, an independent predictor of respiratory complications after oncological esophagectomy

Diseases of the Esophagus : Official Journal of the International Society for Diseases of the Esophagus
D SomaN Kokudo

Abstract

Surgery for esophageal carcinoma is known to be associated with high morbidity. Recent studies have reported a correlation of nutritional and inflammatory parameters with postoperative course. This study aims to clarify the risk factors for operative morbidity after resection of esophageal carcinoma. Consecutive patients who underwent esophagectomy for esophageal squamous cell carcinoma at our institute were included (n = 102; 89 males and 13 females; mean age: 67.3 years). Clinicopathological characteristics, presence or absence of sarcopenia, and modified Glasgow prognostic score were assessed, and their correlation with postoperative complications was investigated using univariate and multivariate analyses. Sarcopenia was defined using a combination of muscle mass area and body mass index. Of the included 102 patients, 45 (44.1%) exhibited sarcopenia (sarcopenia group), while 57 (55.9%) did not (non-sarcopenia group). No significant difference was observed between the groups regarding surgical procedures and tumor stage; furthermore, there was no mortality. Twenty-six patients developed respiratory complications (including 20 cases of pneumonia). On univariate analysis, sarcopenia, modified Glasgow prognostic score, and Amer...Continue Reading

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Citations

Feb 11, 2020·Annals of Surgical Oncology·Pei-Yu WangYin Li
Mar 21, 2020·Diseases of the Esophagus : Official Journal of the International Society for Diseases of the Esophagus·Dimitrios PapaconstantinouEmmanouil Pikoulis
Jul 8, 2020·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·G SheillE Guinan
Feb 7, 2021·Journal of Cardiothoracic and Vascular Anesthesia·Ryan S D'SouzaMichael J Brown

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