Sarcopenic obesity and associations with mortality in older women and men - a prospective observational study

BMC Geriatrics
Åsa von BerensTommy Cederholm

Abstract

The combined effect of sarcopenia and obesity, i.e., sarcopenic obesity, has been associated with disability and worse outcomes in older adults, but results are conflicting. The objectives of this study were to describe the prevalence of sarcopenic obesity (SO) in older adults, and to examine how the risk of mortality is associated with SO and its various components. Data were obtained from two Swedish population studies, the Gothenburg H70 Birth Cohort Studies of 521 women and men at the age of 75, and the Uppsala Longitudinal Study of Adult Men (ULSAM), which included 288 men aged 87 years. Sarcopenia was defined using the recently updated EWGSOP2 definition. Obesity was defined by any of three established definitions: body mass index ≥30 kg/m2, fat mass > 30%/ > 42% or waist circumference ≥ 88 cm/≥102 cm for women and men, respectively. The Kaplan-Meier survival curve and the Cox proportional hazard model were used for 10-year and 4-year survival analyses in the H70 and ULSAM cohorts, respectively. SO was observed in 4% of the women and 11% of the men in the H70 cohort, and in 10% of the ULSAM male cohort. The 75-year-old women with SO had a higher risk (HR 3.25, 95% confidence interval (1.2-8.9)) of dying within 10 years co...Continue Reading

References

Jul 15, 1995·BMJ : British Medical Journal·M E LeanC E Morrison
Sep 1, 2000·The American Journal of Clinical Nutrition·D GallagherY Sakamoto
Feb 11, 2004·American Journal of Epidemiology·Ian JanssenRonenn Roubenoff
Apr 25, 2007·Archives of Internal Medicine·Soham Al SnihJames S Goodwin
Apr 9, 2008·Nutrition, Metabolism, and Cardiovascular Diseases : NMCD·Mauro ZamboniVincenzo Di Francesco
Nov 18, 2008·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Marja TengvallIngvar Bosaeus
Jan 12, 2010·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·H K VincentK M Lamb
Apr 16, 2010·Age and Ageing·Alfonso J Cruz-JentoftUNKNOWN European Working Group on Sarcopenia in Older People
Aug 13, 2010·Interdisciplinary Topics in Gerontology·Ian M Chapman
Jul 24, 2012·Age and Ageing·Fredrik TossAnna Nordström
Dec 12, 2012·Epidemiologic Reviews·Laura A SchaapMarjolein Visser
Mar 26, 2013·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Karissa L CanningJennifer L Kuk
Aug 21, 2013·American Journal of Public Health·Ryan K MastersBruce G Link
Jan 24, 2014·The American Journal of Clinical Nutrition·Jane E WinterCaryl A Nowson
Jan 13, 2015·TheScientificWorldJournal·Valéria Pagotto, Erika Aparecida Silveira
Dec 3, 2015·Current Obesity Reports·Lydia E GillJohn A Batsis
Jul 20, 2016·Annual Review of Nutrition·Brandon J F GhellerAnna E Thalacker-Mercer
Oct 26, 2016·Nutrition, Metabolism, and Cardiovascular Diseases : NMCD·A SpahillariR V Shah
Sep 20, 2016·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·T CederholmP Singer
Nov 29, 2016·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Stephan C BischoffRocco Barazzoni
Jan 18, 2017·PloS One·Charlotte BeaudartOlivier Bruyère
Dec 11, 2017·Advances in Experimental Medicine and Biology·Franck Mauvais-Jarvis
Oct 13, 2018·Age and Ageing·Alfonso J Cruz-JentoftUNKNOWN Writing Group for the European Working Group on Sarcopenia in Older People 2 (EWGSOP2), and the Extended Group for EWGSOP2

❮ Previous
Next ❯

Citations

Sep 13, 2020·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Naoki AkazawaHideki Moriyama
Jul 7, 2021·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Qianqian GaoBin Ma
Jul 3, 2021·Experimental Gerontology·Felipe M de SantanaRosa M R Pereira

❮ Previous
Next ❯

Methods Mentioned

BETA
X-ray

Software Mentioned

ULSAM

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.