Sarcoplasmic reticulum and calcium signaling in muscle cells: Homeostasis and disease

International Review of Cell and Molecular Biology
Roberto Bravo-SaguaSergio Lavandero

Abstract

The sarco/endoplasmic reticulum is an extensive, dynamic and heterogeneous membranous network that fulfills multiple homeostatic functions. Among them, it compartmentalizes, stores and releases calcium within the intracellular space. In the case of muscle cells, calcium released from the sarco/endoplasmic reticulum in the vicinity of the contractile machinery induces cell contraction. Furthermore, sarco/endoplasmic reticulum-derived calcium also regulates gene transcription in the nucleus, energy metabolism in mitochondria and cytosolic signaling pathways. These diverse and overlapping processes require a highly complex fine-tuning that the sarco/endoplasmic reticulum provides by means of its numerous tubules and cisternae, specialized domains and contacts with other organelles. The sarco/endoplasmic reticulum also possesses a rich calcium-handling machinery, functionally coupled to both contraction-inducing stimuli and the contractile apparatus. Such is the importance of the sarco/endoplasmic reticulum for muscle cell physiology, that alterations in its structure, function or its calcium-handling machinery are intimately associated with the development of cardiometabolic diseases. Cardiac hypertrophy, insulin resistance and ar...Continue Reading

Citations

May 22, 2021·Frontiers in Physiology·Arkady UryashJose R Lopez
May 18, 2021·Frontiers in Cell and Developmental Biology·Gaetano SantulliGiampaolo Morciano
Aug 25, 2021·The International Journal of Biochemistry & Cell Biology·R Viswambari DeviMukesh Doble

❮ Previous
Next ❯

Related Concepts

Related Feeds

Calcium & Bioenergetics

Bioenergetic processes, including cellular respiration and photosynthesis, concern the transformation of energy by cells. Here is the latest research on the role of calcium in bioenergetics.

Related Papers

Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme
H Suzuki
Diabetes & Vascular Disease Research : Official Journal of the International Society of Diabetes and Vascular Disease
Gang LiuXiao Yong Tong
© 2021 Meta ULC. All rights reserved