PMID: 9435613Jan 22, 1998Paper

Sarcoplasmic reticulum and Na+/Ca2+ exchanger function during early and late relaxation in ventricular myocytes

The American Journal of Physiology
A YaoWilliam H Barry

Abstract

The relative importance of the Na+/Ca2+ exchanger in the initial and terminal phases of relaxation and the decline in the [Ca2+]i transient was investigated in adult rabbit ventricular myocytes loaded with the Ca2+ indicator fluo 3. For electrically stimulated contractions, the peak intracellular Ca2+ concentration ([Ca2+]i) was 700 +/- 87 nM and end-diastolic [Ca2+]i was 239 +/- 30 nM (0.25 Hz, 37 degrees C, 1.08 mM extracellular Ca2+ concentration; n = 14). Abrupt inhibition of Na+/Ca2+ exchange was produced by removal of extracellular Na+ (KCl substitution) and Ca2+ [2 mM Ca(2+)-free ethylene glycol-bis(beta-aminoethyl either)-N,N,N',N'-tetraacetic acid] by means of a rapid switcher device (SW). Abrupt exposure to high K+ induced an action potential, although sufficient Ca2+ remained adjacent to the sarcolemma to induce a contraction (SW beat) and [Ca2+]i transient that were identical in amplitude to those induced by electrical stimulation (ES beat). The initial relaxation and decline in the [Ca2+]i transient was not significantly prolonged by abrupt elimination of the Na+/Ca2+ exchanger, but the rate and extent of the terminal phase of the decline in the [Ca2+]i transient were significantly reduced. The first derivative of ...Continue Reading

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Citations

Feb 9, 2000·American Journal of Physiology. Heart and Circulatory Physiology·M B WagnerR W Joyner
Dec 20, 2003·American Journal of Physiology. Heart and Circulatory Physiology·M Ayoub MirzaJoseph Y Cheung
Jul 17, 2009·American Journal of Physiology. Cell Physiology·Ang Guo, Huang-Tian Yang
Oct 23, 2001·American Journal of Physiology. Heart and Circulatory Physiology·X Q ZhangJ Y Cheung
Jul 19, 2002·American Journal of Physiology. Heart and Circulatory Physiology·Jianliang SongJoseph Y Cheung
Apr 13, 2004·Journal of Applied Physiology·Jianliang SongJoseph Y Cheung
Nov 16, 2001·American Journal of Physiology. Heart and Circulatory Physiology·J AnD F Stowe
Sep 18, 2002·American Journal of Physiology. Heart and Circulatory Physiology·George M TadrosJoseph Y Cheung
Aug 20, 2004·American Journal of Physiology. Cell Physiology·Jingbo HuangGlen F Tibbits
Jan 29, 2005·Journal of Applied Physiology·Belinda A AhlersJoseph Y Cheung
Aug 6, 2013·American Journal of Physiology. Heart and Circulatory Physiology·Xiu Q ZhangCraig H Selzman
Apr 29, 2005·The Japanese Journal of Physiology·Takeo TanaamiWilliam H Barry
Oct 12, 2007·American Journal of Physiology. Cell Physiology·Jingbo HuangGlen F Tibbits
Jun 16, 2009·American Journal of Physiology. Heart and Circulatory Physiology·JuFang WangJoseph Y Cheung
Jun 8, 2010·Circulation Journal : Official Journal of the Japanese Circulation Society·Yoichi KawamuraShigeaki Nonoyama
Sep 18, 2002·Journal of Applied Physiology·Xue-Qian ZhangJoseph Y Cheung

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