Sarcoplasmic reticulum Ca2+ pumping kinetics regulates timing of local Ca2+ releases and spontaneous beating rate of rabbit sinoatrial node pacemaker cells.

Circulation Research
Tatiana M VinogradovaEdward G Lakatta

Abstract

Sinoatrial node cells (SANCs) generate local, subsarcolemmal Ca(2+) releases (LCRs) from sarcoplasmic reticulum (SR) during late diastolic depolarization. LCRs activate an inward Na(+)-Ca(2+) exchange current (I(NCX)), which accelerates diastolic depolarization rate, prompting the next action potential (AP). The LCR period, ie, a delay between AP-induced Ca(2+) transient and LCR appearance, defines the time of late diastolic depolarization I(NCX) activation. Mechanisms that control the LCR period, however, are still unidentified. To determine dependence of the LCR period on SR Ca(2+) refilling kinetics and establish links between regulation of SR Ca(2+) replenishment, LCR period, and spontaneous cycle length. Spontaneous APs and SR luminal or cytosolic Ca(2+) were recorded using perforated patch and confocal microscopy, respectively. Time to 90% replenishment of SR Ca(2+) following AP-induced Ca(2+) transient was highly correlated with the time to 90% decay of cytosolic Ca(2+) transient (T-90(C)). Local SR Ca(2+) depletions mirror their cytosolic counterparts, LCRs, and occur following SR Ca(2+) refilling. Inhibition of SR Ca(2+) pump by cyclopiazonic acid dose-dependently suppressed spontaneous SANCs firing up to ≈50%. Cyclopi...Continue Reading

References

Nov 1, 1991·Journal of Molecular and Cellular Cardiology·Y KimuraM Tada
Jan 1, 1993·Physiological Reviews·H IrisawaW Giles
Feb 24, 2001·Pflügers Archiv : European journal of physiology·Y K Ju, D G Allen
Jul 3, 2003·Nature Reviews. Molecular Cell Biology·David H MacLennan, Evangelia G Kranias
Feb 16, 2005·Proceedings of the National Academy of Sciences of the United States of America·Didier X P BrochetHeping Cheng
Jan 13, 2009·American Journal of Physiology. Heart and Circulatory Physiology·Victor A Maltsev, Edward G Lakatta
Mar 12, 2009·Proceedings of the National Academy of Sciences of the United States of America·Yuejin WuMark E Anderson
Aug 8, 2009·Cardiovascular Research·Lynda M BlayneyF Anthony Lai

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Citations

Jul 9, 2011·Pharmacological Reviews·Grace E Stutzmann, Mark P Mattson
Mar 17, 2011·Circulation. Arrhythmia and Electrophysiology·Zhan GaoMark E Anderson
Oct 1, 2014·Physics Reports·Zhilin QuJames N Weiss
Sep 18, 2013·The Journal of Physiology·Michael NivalaZhilin Qu
Oct 2, 2015·Proceedings of the National Academy of Sciences of the United States of America·Hengtao ZhangPaul B Rosenberg
Sep 20, 2011·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Victor A Maltsev, Edward G Lakatta
Apr 22, 2014·Journal of Pharmacological Sciences·Victor A MaltsevEdward G Lakatta
Apr 11, 2015·Frontiers in Physiology·Rebecca A Capel, Derek A Terrar
Mar 6, 2015·Frontiers in Physiology·Yael YanivVictor A Maltsev
Apr 21, 2016·PloS One·Zannatul FerdousFrank Christopher Howarth
Jul 26, 2018·International Journal of Molecular Sciences·Tatiana M VinogradovaEdward G Lakatta
Jun 9, 2018·Circulation. Arrhythmia and Electrophysiology·Tatiana M VinogradovaEdward G Lakatta
Sep 16, 2018·Journal of Comparative Physiology. B, Biochemical, Systemic, and Environmental Physiology·Arnaldo Fim NetoJosé W M Bassani
Sep 1, 2011·Expert Review of Cardiovascular Therapy·Fiona HatchSandra A Jones
Mar 19, 2014·American Journal of Physiology. Heart and Circulatory Physiology·Jie LiuEdward G Lakatta
Aug 12, 2016·Physiological Reviews·Michael J Berridge
Jul 13, 2016·American Journal of Physiology. Heart and Circulatory Physiology·Yue LiTatiana M Vinogradova
Nov 23, 2019·Annual Review of Physiology·Colin H PetersCatherine Proenza
May 16, 2020·Frontiers in Pharmacology·Zsófia KohajdaNorbert Nagy
Jun 15, 2021·Frontiers in Physiology·Konstantin HennisStefanie Fenske
Aug 21, 2020·JACC. Clinical Electrophysiology·Rostislav BychkovEdward G Lakatta
Aug 28, 2021·International Journal of Molecular Sciences·Tatiana M Vinogradova, Edward G Lakatta

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