Sargassum serratifolium attenuates RANKL-induced osteoclast differentiation and oxidative stress through inhibition of NF-κB and activation of the Nrf2/HO-1 signaling pathway

Bioscience Trends
Hong Jae KimYung Hyun Choi

Abstract

Sargassum serratifolium C. Agardh is a marine brown alga that has long been used as an ingredient for food and medicine by many people living along Asian coastlines. Recently, various beneficial effects of extracts or compounds isolated from S. serratifolium have been reported, but their efficacies against bone destruction are unclear. Therefore, in this study, we investigated the inhibitory property of an ethanol extract of S. serratifolium (EESS) on osteoclast differentiation by focusing on the receptor activator of nuclear factor-κB ligand (RANKL)-stimulated osteoclastogenesis model using RAW 264.7 macrophages. Our results demonstrated that EESS reduced RANKL-induced osteoclast differentiation in RAW 264.7 cells, by inhibiting tartrate-resistant acid phosphatase (TRAP) activity and destroying the F-actin ring formation. EESS also attenuated RANKL-induced expressions of key osteoclast-specific genes, such as nuclear factor of activated T cells cytoplasmic 1 (NFATC1), TRAP, cathepsin K and matrix metalloproteinase-9. These effects were mediated by impaired nuclear translocation of nuclear factor (NF)-κB and suppression of IκB-α degradation. In addition, EESS effectively inhibited the production of reactive oxygen species (ROS)...Continue Reading

References

Sep 1, 2000·Science·G A Rodan, T J Martin
Aug 5, 2003·Nature Reviews. Genetics·Steven L Teitelbaum, F Patrick Ross
Aug 9, 2003·Expert Opinion on Drug Safety·Ian R Reid
May 4, 2006·The Journal of Clinical Investigation·M Neale Weitzmann, Roberto Pacifici
Nov 14, 2006·Bone·Masataka Asagiri, Hiroshi Takayanagi
Oct 14, 2008·Clinical Chemistry and Laboratory Medicine : CCLM·Giuseppe BanfiMassimiliano M Corsi
Apr 16, 2010·Annals of the New York Academy of Sciences·Satish SrinivasanNarayan G Avadhani
Apr 28, 2010·Journal of Agricultural and Food Chemistry·Swadesh K DasKazuki Kanazawa
Aug 3, 2011·Orthopedic Reviews·Christoph ZiskovenRüdiger Krauspe
Nov 8, 2011·Advances in Food and Nutrition Research·Tomoyuki Koyama
May 1, 2012·Calcified Tissue International·Stuart H Ralston, Rob Layfield
Jun 26, 2012·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Weon-Jong YoonEun-Sook Yoo
Jan 19, 2013·World Journal of Orthopedics·Yukiko Kuroda, Koichi Matsuo
Apr 25, 2013·Biochemical and Biophysical Research Communications·Weon-Jong YoonEun-Sook Yoo
Jul 5, 2013·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Maria Almeida, Charles A O'Brien
Jan 31, 2014·Current Osteoporosis Reports·Masashi HonmaHiroshi Suzuki
Jul 9, 2014·Molecular and Cellular Biology·Sohyun HongWoojin Jeong
Jul 16, 2014·Journal of Bone Metabolism·Deborah L Galson, G David Roodman
Oct 22, 2014·International Journal of Molecular Sciences·Young Woo KimShin-Yoon Kim
Dec 10, 2014·Journal of Bone Metabolism·Jung Ha Kim, Nacksung Kim
Oct 30, 2015·Journal of Biomedical Science·Yong-Xin SunJiliang Li
Apr 22, 2016·Cellular and Molecular Life Sciences : CMLS·Agnieszka LobodaJozef Dulak
May 10, 2016·Biochemical and Biophysical Research Communications·Niroshani Surangika Soysa, Neil Alles
Jan 31, 2017·Toxicological Research·Kyoung Ah Kang, Jin Won Hyun
Mar 25, 2017·Journal of Clinical Medicine·Kwang-Jin KimYoung-Jin Son
May 20, 2017·Experimental & Molecular Medicine·Bingru LuYueran Zhao
Jul 1, 2017·Annals of the New York Academy of Sciences·Andrey S MarchevMilen I Georgiev
Jul 27, 2017·Toxicological Research·Ahmad SalimiJalal Pourahmad
Sep 29, 2017·Current Opinion in Rheumatology·John A CollinsRichard F Loeser
Oct 20, 2017·Molecules and Cells·Jin Hee ParkSoo Young Lee
Dec 22, 2017·Clinical Cases in Mineral and Bone Metabolism : the Official Journal of the Italian Society of Osteoporosis, Mineral Metabolism, and Skeletal Diseases·Vladana DomazetovicMaria Teresa Vincenzini
Feb 3, 2018·Histochemistry and Cell Biology·Takehito Ono, Tomoki Nakashima
Oct 1, 2016·Le Journal médical libanais. The Lebanese medical journal·Lana El OstaHazem El Osta

❮ Previous
Next ❯

Citations

Nov 15, 2019·Molecular and Cellular Biochemistry·Emma HarperPhilip M Cummins
Aug 3, 2019·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Luane Macêdo de SousaDelane Viana Gondim
Nov 22, 2020·Marine Drugs·Lei CaoHyeung-Rak Kim
Jun 4, 2021·European Journal of Pharmacology·Jingmin ChePeng Shang

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antiparasitics

Antiparasitics are medications which are indicated for the treatment of parasitic diseases. Discover the latest research on antiparasitics here.