SARS and MERS: recent insights into emerging coronaviruses

Nature Reviews. Microbiology
Emmie de WitVincent J Munster

Abstract

The emergence of Middle East respiratory syndrome coronavirus (MERS-CoV) in 2012 marked the second introduction of a highly pathogenic coronavirus into the human population in the twenty-first century. The continuing introductions of MERS-CoV from dromedary camels, the subsequent travel-related viral spread, the unprecedented nosocomial outbreaks and the high case-fatality rates highlight the need for prophylactic and therapeutic measures. Scientific advancements since the 2002-2003 severe acute respiratory syndrome coronavirus (SARS-CoV) pandemic allowed for rapid progress in our understanding of the epidemiology and pathogenesis of MERS-CoV and the development of therapeutics. In this Review, we detail our present understanding of the transmission and pathogenesis of SARS-CoV and MERS-CoV, and discuss the current state of development of measures to combat emerging coronaviruses.

References

Apr 3, 2003·The New England Journal of Medicine·Susan M PoutanenUNKNOWN Canadian Severe Acute Respiratory Syndrome Study Team
Apr 3, 2003·The New England Journal of Medicine·Kenneth W TsangKar N Lai
Apr 16, 2003·The New England Journal of Medicine·Nelson LeeJoseph J Y Sung
Apr 12, 2003·The New England Journal of Medicine·Christian DrostenHans Wilhelm Doerr
Apr 12, 2003·The New England Journal of Medicine·Thomas G KsiazekUNKNOWN SARS Working Group
Apr 25, 2003·Lancet·J S M PeirisUNKNOWN SARS study group
May 8, 2003·JAMA : the Journal of the American Medical Association·Christopher M BoothAllan S Detsky
Jul 9, 2003·Lancet·Haroon Ashraf
Dec 17, 2003·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·A BergerW Preiser
Dec 25, 2003·JAMA : the Journal of the American Medical Association·Mona R LoutfyEleanor N Fish
Aug 13, 2004·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Roy M AndersonAnthony J Hedley
Oct 9, 2004·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Wei-Kung WangUNKNOWN Severe Acute Respiratory Syndrome Research Group of the National Taiwan University College of Medicine/NTU Hospital
Dec 21, 2004·Biochemical and Biophysical Research Communications·Birgit MorgensternJindrich Cinatl
Jul 8, 2005·Nature·Yumiko ImaiJosef M Penninger
Sep 20, 2005·Proceedings of the National Academy of Sciences of the United States of America·Susanna K P LauKwok-Yung Yuen
Oct 1, 2005·Science·Wendong LiLin-Fa Wang
Nov 16, 2005·Reviews in Medical Virology·Jason D Graci, Craig E Cameron
Feb 21, 2006·Emerging Infectious Diseases·Ming WangJianguo Xu
May 13, 2006·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Tracey BaasMichael G Katze
May 13, 2006·The Journal of General Virology·Alexander O PasternakEric J Snijder
Mar 1, 2007·Emerging Infectious Diseases·Lin-Fa WangBryan T Eaton
Nov 28, 2008·Proceedings of the National Academy of Sciences of the United States of America·Michelle M BeckerMark R Denison
Dec 17, 2008·PLoS Pathogens·Timothy SheahanMark T Heise
May 1, 2009·PloS One·Yu LeiJenny P-Y Ting
May 12, 2009·Nature Reviews. Microbiology·Stanley Perlman, Jason Netland
Jun 23, 2009·Expert Review of Vaccines·Rachel L Roper, Kristina E Rehm
Oct 20, 2009·Nature Structural & Molecular Biology·Wataru KamitaniShinji Makino

❮ Previous
Next ❯

Citations

Dec 22, 2016·Pharmaceuticals·Víctor M GonzálezAna García-Sacristán
Feb 18, 2017·Pathogens·Alexandra Schäfer, Ralph S Baric
Mar 30, 2017·ELife·Paul-Yannick Bitome-EssonoChristophe Paupy
May 10, 2017·Proceedings of the National Academy of Sciences of the United States of America·Xufang DengSusan C Baker
Feb 15, 2017·BMC Infectious Diseases·Shih-Chao LinChi-Chen Lin
Nov 27, 2016·Current Opinion in Virology·Miranda de GraafConstance Schultsz
Dec 22, 2016·Emerging Microbes & Infections·Jean Kaoru MilletGary R Whittaker
Feb 28, 2018·Frontiers in Immunology·Joseph PrescottVincent Jacobus Munster
Oct 8, 2017·Protein Science : a Publication of the Protein Society·Melanie H DietrichThilo Stehle
May 16, 2018·Proceedings of the National Academy of Sciences of the United States of America·Wentao LiBerend-Jan Bosch
Aug 30, 2017·FEBS Letters·Jian Lei, Rolf Hilgenfeld
Apr 24, 2018·Journal of Investigative Medicine : the Official Publication of the American Federation for Clinical Research·Dima Dandachi, Maria C Rodriguez-Barradas
Aug 29, 2018·Evolution; International Journal of Organic Evolution·Rohan MaddamsettiJustin R Meyer
May 11, 2019·Archiv der Pharmazie·Çağla Begüm ApaydınZafer Cesur
Jun 30, 2018·Current Computer-aided Drug Design·Md Mostafijur RahmanYearul Kabir
Feb 13, 2018·Yonsei Medical Journal·Soo Jin OhOk Sarah Shin
May 30, 2019·EcoHealth·Sophie ZhuSharon L Deem
Aug 26, 2017·The Journal of General Virology·Sonu SubudhiVikram Misra
Sep 4, 2019·ELife·Gideon J MordecaiCurtis A Suttle
Jul 10, 2019·Annual Review of Virology·Pradeep D UchilWalther Mothes
Aug 9, 2017·Journal of Clinical Immunology·Kathleen E SullivanMimi L K Tang
Nov 15, 2019·Journal of Enzyme Inhibition and Medicinal Chemistry·Seri JoMi-Sun Kim
Aug 23, 2019·Chemical Biology & Drug Design·Seri JoMi-Sun Kim
Jan 24, 2020·JAMA : the Journal of the American Medical Association·Catharine I PaulesAnthony S Fauci
Jan 25, 2020·The New England Journal of Medicine·Vincent J MunsterEmmie de Wit
Jul 1, 2017·Science Translational Medicine·Timothy P SheahanRalph S Baric
Feb 1, 2020·European Journal of Clinical Investigation·Matteo BassettiDaniele Roberto Giacobbe
Feb 8, 2020·Clinical Chemistry·Daniel K W ChuLeo L M Poon
Feb 8, 2020·JAMA : the Journal of the American Medical Association·Dawei WangZhiyong Peng

❮ Previous
Next ❯

Methods Mentioned

BETA
nuclear translocation

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.