SARS-CoV-2 cell entry and targeted antiviral development.

Acta Pharmaceutica Sinica. B
Zinuo ChenQinghua Cui

Abstract

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the causative agent of the pandemic coronavirus disease 2019 (COVID-19), which threatens human health and public safety. In the urgent campaign to develop anti-SARS-CoV-2 therapies, the initial entry step is one of the most appealing targets. In this review, we summarize the current understanding of SARS-CoV-2 cell entry, and the development of targeted antiviral strategies. Moreover, we speculate upon future directions toward next-generation of SARS-CoV-2 entry inhibitors during the upcoming post-pandemic era.

References

Mar 27, 2009·Proceedings of the National Academy of Sciences of the United States of America·Sandrine BelouzardGary R Whittaker
Nov 22, 2013·Journal of Virology·Longping V TseGary R Whittaker
Dec 3, 2013·Handbook of Experimental Pharmacology·Eugenia V Gurevich, Vsevolod V Gurevich
Oct 8, 2014·Proceedings of the National Academy of Sciences of the United States of America·Jean Kaoru Millet, Gary R Whittaker
Aug 25, 2015·Nature Medicine·Hadi M YassineBarney S Graham
Aug 26, 2015·Science·Antonietta ImpagliazzoKatarina Radošević
Mar 5, 2016·Traffic·Judith M White, Gary R Whittaker
Sep 28, 2016·Expert Opinion on Investigational Drugs·A L MoekotteM P Grobusch
Oct 30, 2016·Proceedings of the National Academy of Sciences of the United States of America·Jung-Eun ParkTom Gallagher
Oct 20, 2018·Nature Immunology·Erica Ollmann SaphireGalit Alter
Dec 12, 2018·Nature Reviews. Microbiology·Jie CuiZheng-Li Shi
Jan 19, 2020·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·David S HuiEskild Petersen
Jan 28, 2020·Lancet·Chen WangGeorge F Gao
Feb 13, 2020·Cellular & Molecular Immunology·Shuai XiaLu Lu
Feb 20, 2020·The New England Journal of Medicine·Lirong ZouJie Wu
Feb 23, 2020·Science·Daniel WrappJason S McLellan
Mar 4, 2020·Nature Microbiology·UNKNOWN Coronaviridae Study Group of the International Committee on Taxonomy of Viruses
Mar 11, 2020·Cell·Alexandra C WallsDavid Veesler
Mar 28, 2020·Nature·Xiaoping HanGuoji Guo
Apr 1, 2020·Nature·Jian ShangFang Li
Apr 14, 2020·The Journal of Infection·Zhen ZhuYuan Xue
Apr 22, 2020·Antimicrobial Agents and Chemotherapy·Markus HoffmannStefan Pöhlmann

❮ Previous
Next ❯

Software Mentioned

AlphaScreen

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.