SARS-CoV-2 COVID-19 susceptibility and lung inflammatory storm by smoking and vaping.

Journal of Inflammation
G. KaurIrfan Rahman

Abstract

The current pandemic of COVID-19 has caused severe morbidity and mortality across the globe. People with a smoking history have severe disease outcomes by COVID-19 infection. Epidemiological studies show that old age and pre-existing disease conditions (hypertension and diabetes) result in severe disease outcome and mortality amongst COVID-19 patients. Evidences suggest that the S1 domain of the SARS-CoV-2 (causative agent of COVID-19) membrane spike has a high affinity towards the angiotensin-converting enzyme 2 (ACE2) receptor found on the host's lung epithelium. Likewise, TMPRSS2 protease has been shown to be crucial for viral activation thus facilitating the viral engulfment. The viral entry has been shown to cause 'cytokine storm' involving excessive production of pro-inflammatory cytokines/chemokines including IL-6, TNF-α, IFN-γ, IL-2, IL-7, IP-10, MCP-3 or GM-CSF, which is augmented by smoking. Future research could target these inflammatory-immunological responses to develop effective therapy for COVID-19. This mini-review provides a consolidated account on the role of inflammation and immune responses, proteases, and epithelial permeability by smoking and vaping during SARS-CoV2 infection with future directions of rese...Continue Reading

References

Jun 24, 1998·Proceedings of the National Academy of Sciences of the United States of America·F JeanG Thomas
Nov 1, 2003·The Lancet Infectious Diseases·Andrea SavarinoRoberto Cauda
Nov 10, 2004·Archives of Internal Medicine·Lidia Arcavi, Neal L Benowitz
Mar 7, 2007·Journal of Cellular Biochemistry·Renda Soylemez WienerMary C Williams
Jan 5, 2008·American Journal of Respiratory and Critical Care Medicine·Saravanan RajendrasozhanIrfan Rahman
Apr 8, 2011·American Journal of Respiratory and Critical Care Medicine·Cynthia GordonRonald G Crystal
Aug 30, 2013·Medicina oral, patología oral y cirugía bucal·Antonio Bascones-MartinezJukka H Meurman
Nov 26, 2015·American Journal of Respiratory Cell and Molecular Biology·Rangnath MishraJames H Finigan
Jan 26, 2016·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·John H HwangLaura E Crotty Alexander
Jul 8, 2017·Chest·Hiroshi Kubo
Sep 22, 2017·American Journal of Respiratory Cell and Molecular Biology·Mahyar AghapourIrene H Heijink
Jan 8, 2020·JAMA : the Journal of the American Medical Association·Lisa SandersGordon D Schiff
Feb 26, 2020·International Journal of Oral Science·Hao XuQianming Chen
Mar 10, 2020·Drug Discoveries & Therapeutics·Liying DongJianjun Gao
Mar 14, 2020·The Journal of Clinical Investigation·Arturo Casadevall, Liise-Anne Pirofski
Mar 15, 2020·The Lancet. Respiratory Medicine·Lei FangMichael Roth
Mar 19, 2020·The New England Journal of Medicine·Bin CaoChen Wang
Mar 21, 2020·European Journal of Internal Medicine·Giuseppe Lippi, Brandon Michael Henry
Mar 25, 2020·International Journal of Antimicrobial Agents·Philippe GautretDidier Raoult
Mar 25, 2020·Cell Death and Differentiation·Yufang ShiGerry Melino
Apr 4, 2020·American Journal of Respiratory and Critical Care Medicine·Yingzhen DuGuogang Xu
Apr 4, 2020·JAMA Cardiology·Chirag BavishiFranz H Messerli
Apr 10, 2020·The European Respiratory Journal·Janice M LeungDon D Sin
Apr 10, 2020·Ecancermedicalscience·Omolola SalakoBabatunde Salako
Apr 11, 2020·The New England Journal of Medicine·Jonathan GreinTimothy Flanigan
Apr 12, 2020·Cancer Discovery·Konrad H StopsackPhilip W Kantoff
Apr 14, 2020·Journal of Pharmaceutical Analysis·Xiaowei LiShemin Lu
Apr 18, 2020·The Journal of Experimental Medicine·Betsy J BarnesMikala Egeblad

❮ Previous
Next ❯

Citations

Oct 10, 2020·The Journal of Pharmacology and Experimental Therapeutics·Ali Ehsan SifatThomas J Abbruscato
Dec 16, 2020·Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco·Jonathan M Samet
Dec 22, 2020·JMIR Public Health and Surveillance·Yankun GaoDongmei Li
Dec 1, 2020·Respiratory Medicine·Alpana Kumar GuptaRavi Mehrotra
Mar 2, 2021·Tobacco Use Insights·Chadia HaddadPascale Salameh
Mar 30, 2021·Drug Discovery Today·Gilbert HoMakoto Hashimoto
Apr 6, 2021·Frontiers in Physiology·Jianghua XieYanhui Zou
Apr 24, 2021·The Journal of Infection·Alexander J StockdaleElizabeth Joekes
Apr 24, 2021·Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco·Sang Chul LeeSeon Cheol Park
Jun 1, 2021·Frontiers in Pediatrics·Esha BrarXin Li
Aug 24, 2021·Chemické Zvesti·Wafaa Waleed Al-Qaysi, Fatma H Abdulla
Sep 10, 2021·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·Santosh KumarJohn Bissler
Jan 13, 2022·Problemy e̊ndokrinologii·S S ShklyaevN G Mokrysheva

❮ Previous
Next ❯

Software Mentioned

EVALI
ENDS

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Computational and Structural Biotechnology Journal
Ishita GuptaAla-Eddin Al Moustafa
International Journal of Molecular Sciences
Vivek K KashyapSubhash C Chauhan
The European Respiratory Journal
Kielan Darcy McAlindenSukhwinder Singh Sohal
Journal of Medical Virology
Biying HuLianghong Yin
© 2022 Meta ULC. All rights reserved