SARS-CoV-2 droplet deposition path and its effects on the human upper airway in the oral inhalation.

Computer Methods and Programs in Biomedicine
Hamed MortazaviSeyed Hossein Sajadian

Abstract

It is crucial to study the uptake of viral droplets in the human respiratory system to control, prevent, and treat diseases. In this study, a well-verified real anatomical model was used; the passage of air in the human upper respiratory system computed using high-quality Computer Tomography (CT) images. Then, the airflow field, along with the coronavirus micro-droplets injection, was examined in this realistic model using the Fluid-Structure Interaction (FSI) method. The Discrete Phase Model (DPM) was used to solve the field, and with the help of it, the accurate assessment of the temporal and spatial motion of the deposition in the virus-impregnated droplets was obtained in vitro in the upper respiratory system. The results show that the amount of deposited micro-droplets in the nasal cavity area is meager at the inhalation only through the oral. However, it has the most residence time in this area. The most and least droplet absorption occurred in the oral cavity and larynx-trachea, respectively. Deposition efficiency is about 100% in 30 L/min flow rate and 10 μm diameter; in other words, no droplet enters the lungs. This study's other achievements include the relatively inverse relationship between droplets deposition effic...Continue Reading

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Citations

Mar 2, 2021·Biomechanics and Modeling in Mechanobiology·Hamidreza Mortazavy BeniSanam Kamalipour
Jun 22, 2021·Physics of Fluids·Mohammad S IslamSuvash C Saha

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