SARS-CoV-2-Encoded Proteome and Human Genetics: From Interaction-Based to Ribosomal Biology Impact on Disease and Risk Processes.

Journal of Proteome Research
Olivia SirpillaJeremy W Prokop

Abstract

SARS-CoV-2 (COVID-19) has infected millions of people worldwide, with lethality in hundreds of thousands. The rapid publication of information, both regarding the clinical course and the viral biology, has yielded incredible knowledge of the virus. In this review, we address the insights gained for the SARS-CoV-2 proteome, which we have integrated into the Viral Integrated Structural Evolution Dynamic Database, a publicly available resource. Integrating evolutionary, structural, and interaction data with human proteins, we present how the SARS-CoV-2 proteome interacts with human disorders and risk factors ranging from cytokine storm, hyperferritinemic septic, coagulopathic, cardiac, immune, and rare disease-based genetics. The most noteworthy human genetic potential of SARS-CoV-2 is that of the nucleocapsid protein, where it is known to contribute to the inhibition of the biological process known as nonsense-mediated decay. This inhibition has the potential to not only regulate about 10% of all biological transcripts through altered ribosomal biology but also associate with viral-induced genetics, where suppressed human variants are activated to drive dominant, negative outcomes within cells. As we understand more of the dynami...Continue Reading

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Citations

Mar 30, 2021·Expert Review of Proteomics·Nicholas HartogJeremy W Prokop
May 7, 2021·Brazilian Journal of Microbiology : [publication of the Brazilian Society for Microbiology]·Luciano Rodrigo Lopes
Dec 11, 2020·Journal of Proteome Research·Suvobrata Chakravarty

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Methods Mentioned

BETA
affinity purification
NMR
two hybrid
X-ray
GTPases
PLAT
dissections
protein folding
RNaseq

Software Mentioned

ITASSER
BLAST
VIStEDD
Basic Local Alignment Search Tool ( BLAST )
ClinVar

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