SARS-CoV-2 has displaced other seasonal respiratory viruses: Results from a prospective cohort study.

The Journal of Infection
Stephen PooleTristan W Clark

Abstract

The effect of SARS-CoV-2 on existing respiratory viruses in circulation and the overall burden of viral respiratory disease remains uncertain. Traditionally, severe viral respiratory disease disproportionally affects those with underlying chronic lung diseases. This study aimed to assess the impact of SARS-CoV-2 on the prevalence and clinical characteristics of respiratory virus disease in hospitalised adults. Data for this cohort study were from hospitalised adults who had multiplex PCR testing for respiratory viruses over several seasons in Hampshire, UK. Respiratory virus detection during the first epidemic peak of SARS-CoV-2 was compared to detection during the same time period across previous years. 856 patients had multiplex PCR for respiratory viruses between March and May over 5 years. Before 2020, a non-SARS-CoV-2 virus was detected in 54% patients (202/371) compared to 4.1% (20/485) in 2020 (p < 0.0001). SARS-CoV-2 was associated with asthma or COPD exacerbations in a smaller proportion of infected patients compared to other viruses (1.0% vs 37%, p < 0.0001). The emergence of SARS-CoV-2 was associated with substantial reductions in the circulation of seasonal respiratory viruses and large differences in the characteri...Continue Reading

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Citations

Jul 18, 2021·Pediatric Pulmonology·Greta Di MattiaFabio Midulla
Aug 23, 2021·The Journal of Infection·Alexandra BramleyTabitha W Mahungu
Aug 28, 2021·Biology·Irina Kiseleva, Andrey Ksenafontov
Sep 30, 2021·American Journal of Physiology. Lung Cellular and Molecular Physiology·David M G HalpinAlvar Agusti

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Methods Mentioned

BETA
X-ray

Clinical Trials Mentioned

ISRCTN90211642
ISRCTN17197293
ISRCTN14966673

Software Mentioned

GraphPad Prism
GraphPad

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