SARS-CoV-2 in the semen: Where does it come from?

Andrology
Claudia MassarottiCarlo Foresta

Abstract

The recent report of SARS-CoV-2 presence in semen samples of six patients, including two subjects who were recovering from the clinical disease, re-opened the discussion on possible male genital tract infection, virus shedding in semen, sexual transmission and safety of fertility treatments during the pandemic period. To explore current data and hypothesis on the possible sites of SARS-CoV-2 infection in the male reproduction system. We reviewed the current literature to describe: a) the evidences on angiotensin-converting enzyme 2 (AC2E) and transmembrane serine protease 2 (TMPRSS2) expression in the testes, accessory glands (including prostate) and the urinary tract; b) other coronaviruses' (SARS and MERS) ability to infect these sites. The co-expression of both ACE2 and TMPRSS2 genes was reported in spermatogonial stem cells, elongated spermatids, in at least a small percentage of prostate hillock cells and in renal tubular cells. Testicular damage was described in autopsies of SARS patients, without evidence of the virus in the specimens. Prostate is a known infection site for MERS-CoV. SARS-CoV-2 was detected in urines. There are still al lot of open questions on the effects of SARS-CoV-2 infection on the male reproductive...Continue Reading

References

Oct 3, 2017·The Journal of Infectious Diseases·Jennifer L SpencerRebecca R Rico-Hesse
Feb 23, 2020·Biochemical and Biophysical Research Communications·Yun ChenZhizhuang Joe Zhao
Apr 12, 2020·Cancer Discovery·Konrad H StopsackPhilip W Kantoff
Apr 23, 2020·World Journal of Urology·Anis Abobaker, Ali Ahmed Raba
Apr 28, 2020·Endocrine, Metabolic & Immune Disorders Drug Targets·Thea MagroneEmilio Jirillo
Apr 30, 2020·Infectious Diseases of Poverty·Meng-Yuan LiXiao-Sheng Wang
May 19, 2020·European Urology·Hanbing SongFranklin W Huang
May 27, 2020·Andrology·Donatella PaoliFrancesco Lombardo

❮ Previous
Next ❯

Citations

Nov 18, 2020·Journal of Medical Virology·Cemile Merve Seymen
Mar 18, 2021·Hormones : International Journal of Endocrinology and Metabolism·Alev SelekŞinasi Erol Bolu
Jun 2, 2021·Systems Biology in Reproductive Medicine·George AnifandisIoannis E Messinis
Jun 10, 2021·Therapeutic Advances in Endocrinology and Metabolism·Stefano SalcicciaMartina Maggi
Jun 15, 2021·Frontiers in Endocrinology·Yanfei HeXuejiao Chen
Aug 5, 2021·Journal of Sex & Marital Therapy·Sedigheh AbdollahpourTalat Khadivzadeh

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

© 2021 Meta ULC. All rights reserved