SARS-CoV-2 induced thrombocytopenia as an important biomarker significantly correlated with abnormal coagulation function, increased intravascular blood clot risk and mortality in COVID-19 patients

Experimental Hematology & Oncology
Changqian BaoWenbin Qian

Abstract

Coronavirus disease 2019 (COVID-19) is a novel infectious viral disease, which lacks well-established diagnostic laboratory parameters that could be used to evaluate disease severity, thromboembolism or cardiovascular events and to predict clinical prognosis. Coagulation cascade and platelet functions have not been well studied in the COVID-19 patients. A total of 178 patients enrolled in Wuhan Huoshenshan Hospital were included for the study. Blood platelets and coagulation functions were analyzed in COVID-19 patients with non-severe and severe subgroups. Other biochemical laboratory parameters were also analyzed. Forty-nine (27.5%) out of 178 patients were diagnosed with severe disease in this study, and 129 patients with non-severe disease. Severe disease group had significant lower platelet count 186.00 (103.50-249.00) ×109/L than 251.00 (202.00-317.00) ×109/L of non-severe group, p = 0.000. Severe group also had significantly abnormal coagulation parameters than non-severe group: prothrombin time (PT) 14.55 (13.40-16.53) s vs. 12.70 (12.15-13.59) s, p = 0.000; international normalized ratio (INR) 1.21 (1.13-1.36) vs. 1.06 (1.01-1.13), p = 0.000; thrombin time (TT) 16.35 (15.69-17.47) s vs. 15.68 (14.79-16.69) s, p = 0.011;...Continue Reading

References

Apr 3, 2002·Seminars in Liver Disease·Lucio AmitranoAntonio Balzano
Oct 4, 2016·Frontiers in Immunology·Maria Fernanda PascuttiMartijn A Nolte
Jul 10, 2018·Current Opinion in Hematology·Harvey G RowethKellie R Machlus
Feb 29, 2020·The New England Journal of Medicine·Wei-Jie GuanUNKNOWN China Medical Treatment Expert Group for Covid-19
Mar 18, 2020·Clinica Chimica Acta; International Journal of Clinical Chemistry·Giuseppe LippiBrandon Michael Henry
Apr 12, 2020·Journal of Thrombosis and Haemostasis : JTH·Ariunzaya Amgalan, Maha Othman
Apr 14, 2020·American Journal of Hematology·Evangelos TerposMeletios A Dimopoulos
Apr 16, 2020·Journal of Thrombosis and Haemostasis : JTH·Deepa R J Arachchillage, Mike Laffan
Apr 17, 2020·Annals of Hematology·Panyang XuJiancheng Xu
Apr 18, 2020·Journal of Thrombosis and Haemostasis : JTH·Xiaobo YangYou Shang
Apr 20, 2020·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Dimitrios GiannisPanagiota Gianni

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Citations

Oct 18, 2020·Journal of Clinical Pathology·Alexandros Rampotas, Sue Pavord
Oct 21, 2020·Annals of Hematology·Hong-Chun LuoYue-Qiang Fu
Oct 13, 2020·Radiation Research·Pataje G PrasannaKathryn D Held
Feb 2, 2021·Experimental Hematology & Oncology·Runhui ZhengLing Sang
Jan 30, 2021·Epidemiology and Infection·Raymond PranataRaden Ayu Tuty Kuswardhani
Mar 9, 2021·Indian Journal of Hematology & Blood Transfusion : an Official Journal of Indian Society of Hematology and Blood Transfusion·Hakan Keski
Mar 9, 2021·Frontiers in Medicine·Yuanyuan ChenZhongji Meng
Apr 17, 2021·Frontiers in Pediatrics·Madhusudan Samprathi, Muralidharan Jayashree
Apr 28, 2021·Critical Care : the Official Journal of the Critical Care Forum·Pengping LiHongshan Chen
May 5, 2021·Cell Biology International·Mahdi Kohansal VajariDavood Bashash
Jul 28, 2021·Advances in Medical Sciences·Angelo ZinelluArduino A Mangoni
Aug 11, 2021·Experimental and Therapeutic Medicine·Oana-Viola BadulescuCiprian Rezus
Aug 28, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Amin IslamShereen Elshazly

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Methods Mentioned

BETA
reverse transcription PCR
PCR

Software Mentioned

GraphPad Prism
Social Sciences ( SPSS )

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