SARS-CoV-2 Infection and High-Risk Non-Muscle-Invasive Bladder Cancer: Are There Any Common Features?

Urologia Internationalis
Gian Maria BusettoMatteo Ferro

Abstract

The new severe acute respiratory syndrome virus (SARS-CoV-2) outbreak is a huge health, social and economic issue and has been declared a pandemic by the World Health Organization. Bladder cancer, on the contrary, is a well-known disease burdened by a high rate of affected patients and risk of recurrence, progression and death. The coronavirus disease (COVID-19 or 2019-nCoV) often involves mild clinical symptoms but in some cases, it can lead to pneumonia with acute respiratory distress syndrome and multiorgan dysfunction. Factors associated with developing a more severe disease are increased age, obesity, smoking and chronic underlying comorbidities (including diabetes mellitus). High-risk non-muscle-invasive bladder cancer (NMIBC) progression and worse prognosis are also characterized by a higher incidence in patients with risk factors similar to COVID-19. Immune system response and inflammation have been found as a common hallmark of both diseases. Most severe cases of COVID-19 and high-risk NMIBC patients at higher recurrence and progression risk are characterized by innate and adaptive immune activation followed by inflammation and cytokine/chemokine storm (interleukin [IL]-2, IL-6, IL-8). Alterations in neutrophils, lymph...Continue Reading

References

Aug 13, 2003·The EMBO Journal·Christian M BeauséjourJudith Campisi
May 4, 2007·The Journal of Clinical Investigation·Wan-Wan Lin, Michael Karin
Aug 2, 2007·Nature Reviews. Molecular Cell Biology·Judith Campisi, Fabrizio d'Adda di Fagagna
May 29, 2010·The Oncologist·Kathleen Y WolinGraham A Colditz
Jun 28, 2011·Cancer Microenvironment : Official Journal of the International Cancer Microenvironment Society·Remi-Martin LabergePierre-Yves Desprez
Jul 26, 2011·Nature Reviews. Immunology·Alberto MantovaniSébastien Jaillon
Aug 19, 2011·JAMA : the Journal of the American Medical Association·Neal D FreedmanChristian C Abnet
Sep 15, 2011·International Journal of Urology : Official Journal of the Japanese Urological Association·Eu Chang HwangSoo Bang Ryu
Nov 13, 2012·Annual Review of Physiology·Judith Campisi
Apr 19, 2013·Influenza and Other Respiratory Viruses·Emily T MartinKeith S Kaye
Jul 31, 2013·Immunobiology·Maria Rosaria GaldieroSébastien Jaillon
Aug 21, 2013·Influenza and Other Respiratory Viruses·Noelle M CocorosMichael Klompas
Oct 5, 2014·The Lancet Oncology·Connie I DiakosStephen J Clarke
Nov 14, 2014·Expert Review of Clinical Immunology·David B ThompsonDevendra K Agrawal
Jan 16, 2015·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Jean-François RossiBernard Klein
Mar 13, 2015·PLoS Pathogens·Philipp KrugerDominik Hartl
Mar 25, 2015·Trends in Immunology·Audrey Lasry, Yinon Ben-Neriah
May 25, 2016·Experimental and Clinical Endocrinology & Diabetes : Official Journal, German Society of Endocrinology [and] German Diabetes Association·J WojciechowskaT Zatoński
Jun 22, 2016·European Urology·Marko BabjukRichard Zigeuner
Sep 15, 2016·Future Oncology·Matteo FerroOttavio De Cobelli
May 4, 2017·Seminars in Immunopathology·Rudragouda Channappanavar, Stanley Perlman
Jul 22, 2017·The Cancer Journal·Xinwen ZhangHaiyan Zhang
Jul 29, 2017·International Journal of Clinical Oncology·Xingxing TangYong Yang
Oct 7, 2017·Current Opinion in Urology·Francesco SoriaPaolo Gontero
Feb 7, 2018·Nature Reviews. Clinical Oncology·Daniel E JohnsonJennifer R Grandis
Mar 24, 2018·PloS One·André L A BarbosaLambertus A Kiemeney
Aug 17, 2018·Journal of Immunological Methods·Amir A Sadighi Akha
Nov 10, 2018·Seminars in Immunology·Barbara BottazziAlberto Mantovani
Dec 6, 2018·Influenza and Other Respiratory Viruses·Joe-Ann S MoserUNKNOWN La Red ILI 002 Study Group
Feb 20, 2019·Journal of Cellular Physiology·Pejman ShadpourNadereh Rashtchizadeh
Feb 21, 2019·International Braz J Urol : Official Journal of the Brazilian Society of Urology·Marco RacioppiPier Francesco Bassi
Jan 26, 2020·Journal of Medical Virology·Geng LiJianguo Wu
Feb 8, 2020·JAMA : the Journal of the American Medical Association·Dawei WangZhiyong Peng

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Jun 10, 2021·The Surgery Journal·Mohamad MoussaAthanasios Dellis
Nov 4, 2021·Journal of Cosmetic Dermatology·Francesca MagriMarta Muscianese
Oct 6, 2020·Urologia Internationalis·Paolo CapogrossoFederico Dehò

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